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TranscriptomicsCalcineurin-dependent transcriptome in ICN1 (activated NOTCH1)-induced T cell acute lymphoblastic leukemia (T-ALL)
Activated NOTCH1 induces T-ALL in mice when transduced in bone marrow (BM) cells. T-ALL cells activate the calcineurin/NFAT pathway in vivo (Medyouf H. et al. Nat Med 2007 [PMID 17515895]). Through appropriate crosses, mouse ICN1-induced T-ALL were generated that include a ROSCreERT2 transgene and 2...
ORGANISM(S): Mus musculus 
2014-08-09 | GSE60258 | GEO
TranscriptomicsCalcineurin-dependent transcriptome in ICN1 (activated NOTCH1)-induced T cell acute lymphoblastic leukemia (T-ALL)
Activated NOTCH1 induces T-ALL in mice when transduced in bone marrow (BM) cells. T-ALL cells activate the calcineurin/NFAT pathway in vivo (Medyouf H. et al. Nat Med 2007 [PMID 17515895]). Through appropriate crosses, mouse ICN1-induced T-ALL were generated that include a ROSCreERT2 transgene and 2...
ORGANISM(S): Mus musculus 
2014-08-09 | E-GEOD-60258 | biostudies-arrayexpress
UnknownUnleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts.
Not available
S-EPMC9308469 | biostudies-literature
UnknownMyelodysplasia is in the niche: novel concepts and emerging therapies.
Not available
S-EPMC4320287 | biostudies-literature
GenomicsMus musculus
Calcineurin-dependent transcriptome in ICN1 (activated NOTCH1)-induced T cell acute lymphoblastic leukemia (T-ALL)
PRJNA257825 | ENA
UnknownNFAT transcription factors are essential and redundant actors for leukemia initiating potential in T-cell acute lymphoblastic leukemia.
Not available
S-EPMC8263285 | biostudies-literature
TranscriptomicsHuman T-ALL cell line response to inhibition of Notch signaling
Analysis of five Notch signaling-dependent human T-ALL cell lines (ALLSIL, DND41, HPBALL, KOPTK1, TALL-1) treated with gamma-secretase inhibitor (GSI) to block Notch signaling. Samples include parental cells, cells rescued by retroviral transduction with ICN (a GSI-independent form of activated Notc...
ORGANISM(S): Homo sapiens 
2011-07-31 | E-GEOD-29959 | biostudies-arrayexpress
UnknownMiR144/451 Expression Is Repressed by RUNX1 During Megakaryopoiesis and Disturbed by RUNX1/ETO.
Not available
S-EPMC4798443 | biostudies-literature
UnknownSuppression of RUNX1/ETO oncogenic activity by a small molecule inhibitor of tetramerization.
Not available
S-EPMC5685283 | biostudies-literature
UnknownCRISPR/Cas9-edited NSG mice as PDX models of human leukemia to address the role of niche-derived SPARC.
Not available
S-EPMC7703605 | biostudies-literature
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