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ProteomicsLead Exposure During Development Alters Synaptic Organization and Protein Expression in Rat Hippocampus
Lead (Pb) is a potent neurotoxin with disastrous effects on cognition, memory, and sensory functions. Pb exposure during the developmental stage of life causes irreversible changes in neuronal morphology impacting the physiological functions from reduced motor skills and lowered intelligence quotien...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-12-01 | PXD064482 | Pride
Proteomics Hippocampus Histology Memory Pb toxicity 
ProteomicsImpact of neonatal lead exposure on memory: A study highlighting the association between hippocampal synaptic proteome and cognitive decline in rats
Lead (Pb2+) is a heavy metal ubiquitously present in the environment, with unknown essential functions to sustain life. The detrimental effects of Pb2+ on health are known since ancient times, which is also well supported by scientific literature. Incidentally, Pb2+ toxicity is more severe in childr...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-03-10 | PXD034212 | Pride
Lead toxicity Proteomics Hippocampus Memory impairment 
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