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ProteomicsCigarette smoke alters the secretome of lung epithelial cells
Cigarette smoke is the most relevant risk factor for the development of lung cancer and chronic obstructive pulmonary disease. Many of its more than 4500 chemicals are highly reactive, thereby altering protein structure and function. Here, we used subcellular fractionation coupled to label-free quan...
ORGANISM(S): Homo sapiens (Human) 
2019-01-08 | PXD007180 | Pride
Lung Proteomic profiling Cigarette smoke Secretome 
ProteomicsDissecting the molecular effects of cigarette smoke on proteasome function
Proteasome dysfunction is emerging as a novel pathomechanism for the development of chronic obstructive pulmonary disease (COPD), a major leading cause of death in the world. Cigarette smoke is one of the main risk factors for COPD and has been shown to impair proteasome function in vitro and in viv...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-01-08 | PXD007148 | Pride
Cigarette smoke Proteasome 
TranscriptomicsmRNA expression after siRNA-mediated knock down of Enhancer of zeste homolog 2 (Ezh2) in human umbilical vein endothelial cells
mRNA expression after Ezh2 knock down was analyzed to identify genes regulated by Ezh2. Human umbilical vein endothelial cells (HUVEC) were transfected with 25 nmol/L of control small interfering RNA (siRNA) (Silencer Select Negative Control Ambion, Austin, TX) or siRNA directed against Ezh2 (s4918;...
ORGANISM(S): Homo sapiens 
2012-10-16 | E-GEOD-41610 | biostudies-arrayexpress
TranscriptomicsImmunoproteasome dysfunction augments alternative polarization of alveolar macrophages
The proteasome is a central regulatory hub for intracellular signaling by degrading numerous signaling mediators. Immunoproteasomes are specialized types of proteasomes known to be involved in shaping adaptive immune responses, but their role for innate immune signaling is elusive. Here, we analyzed...
ORGANISM(S): Mus musculus 
2016-06-29 | E-GEOD-72000 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rats with terminal heart failure and cachexia
Rats overexpressing the human renin and angiotensinogen genes die after seven weeks of end organ damage. They develop hypertension, heart hypertrophy and proteinuria.We compared terminal heart failure, these are indeed terminally ill to double transgenic animals suffering on hypertension, proteinuri...
ORGANISM(S): Rattus norvegicus 
2008-06-11 | E-GEOD-1557 | biostudies-arrayexpress
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