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TranscriptomicsClinical relevance of SKP2 alterations in metastatic melanoma
Melanoma cell lines were genotyped to evaluate copy number differences between nodular melanoma (NM) and superficial spreading melanoma (SSM). Cell lines were also evaluated for copy number alterations in the SKP2/p27 axis. Affymetrix SNP arrays were performed according to manufacturer's instruction...
ORGANISM(S): Homo sapiens 
2010-10-21 | E-GEOD-22305 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human melanoma cell lines (63)
63 melanoma cell lines hybridized to Affymetrix Hu133_Plus 2 oligo arrays. The aim of this study was to identify potential downstream targets of key oncogenes and TSGs in melanoma (including p14ARF, p16INK4A, BRAF etc). Publications relevant to this series include:; Johansson et al. Pigment Cell Res...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7127 | biostudies-arrayexpress
MetabolomicsCDK4/6 inhibitor-mediated cell overgrowth triggers an osmotic stress response and chronic p38MAPK activation to promote long-term cell cycle arrest

Cell size and the cell cycle are intrinsically coupled and abnormal increases in cell size are associated with senescence and permanent cell cycle arrest. The mechanism by which overgrowth primes cells to withdraw from the cell cycle remains unknown. We investigate this here using CDK4/6 inhibito...

2025-10-24 | MTBLS5868 | MetaboLights
MetabolomicsSingle-cell and spatial multi-omics reveal a recurrent multicellular niche at the tumor-stroma interface in multidrug resistance
Multi-drug resistance (MDR) is an almost inevitable end point of cancer therapy, driving rapid tumor progression, yet its evolutionary logic remains unclear because MDR tumors are rarely resected. Using paired therapy-naive and MDR melanoma specimens from a clinical trial, integrated with single-cel...
2027-08-13 | MTBLS15322 | MetaboLights
TranscriptomicsGene expression profilling of metastatic melanoma cell lines
Melanoma can progress rapidly from a slow-growing surgically curable lesion to aggressive metastatic disease, with high mortality and poor response to current therapies. The mechanisms underlying melanoma progression and resistance to therapeutic agents are not well understood. There are few treatme...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-16404 | biostudies-arrayexpress
TranscriptomicsMelanoma short-term cultures and cell lines: expression profiling and CNV analyses
This SuperSeries is composed of the following subset Series: GSE17349: Expression data for melanoma short-term cultures and cell lines GSE17359: Affymetrix SNP array data for 3 melanoma short-term cultures and cell lines GSE20156: RNA-Seq of melanoma short-term cultures and cell lines Refer to indiv...
ORGANISM(S): Homo sapiens 
2010-02-01 | E-GEOD-17593 | biostudies-arrayexpress
TranscriptomicsMicroRNA Expression Profiles Associated with Mutational Status and Survival in Malignant Melanoma
In order to improve our understanding of microRNA (miRNA) deregulation in melanoma development and possible consequences for patient survival, miRNA expression profiles were determined, using an array based approach, in melanoma tumors, melanoma cell lines and normal melanocytes. Differentially expr...
ORGANISM(S): Homo sapiens 
2010-04-21 | E-GEOD-19387 | biostudies-arrayexpress
GenomicsLoss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma
DNA methylation at the 5-position of cytosine (5-mC) is a key epigenetic mark critical for varius biological and pathological processes. 5-mC can be converted to 5-hydroxymethylcytosine (5-hmC) by the Ten-Eleven Translocation (TET) family of DNA hydroxylases. Here we report that "loss of 5-hmC&...
ORGANISM(S): Homo sapiens 
2012-09-18 | E-GEOD-38231 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of different human melanoma cells in response to 5-aza-deoxycytidine
(subset of yale_halaban_skinspore_1) expression analysis in response to 5-aza-deoxycytidine and normal melanocytes versus melanoma.
ORGANISM(S): Homo sapiens 
2010-01-18 | E-MTAB-185 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Melanoma cell lines to investigate differences in wild-type p14ARF and mutant 14ARF
35 Melanoma cell lines hybridized to Affymetrix Hu133_Plus 2 microarrays were analysed for genes differentially expressed between cell lines carrying wild-type p14ARF and those with mutant 14ARF. All of these cell lines contained wild-type p53 (so that the effects of p14ARF mutations could be analys...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7152 | biostudies-arrayexpress
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