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ProteomicsProteomics of Primary Uveal Melanoma:Insights to Metastasis and Protein Biomarkers
Uveal melanoma metastases are lethal and remain incurable. Quantitative proteomic analysis of 53 metastasizing and 47 non-metastasizing primary uveal melanoma (pUM) was pursued for insights into UM metastasis and protein biomarkers. The metastatic status of the pUM specimens was defined based on cli...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-05-15 | MSV000087437 | MassIVE
TranscriptomicsDNA methylation analysis of melanoma progression to brain metastasis
Melanoma is one of the most aggressive and treatment-resistant cancers. It represents the most life-threatening neoplasm of the skin, and its incidence has been increasing for the last three decades. Melanoma evolves from the local transformation of melanocytes to primary tumors, which can metastasi...
ORGANISM(S): Homo sapiens 
2013-09-19 | E-GEOD-44661 | biostudies-arrayexpress
TranscriptomicsMelanoma experimental metastasis model
Application of a melanoma experimental metastasis model to elucidate molecular mediators of melanoma brain metastasis. Malignant melanoma frequently metastasizes to the brain. The molecular mediators of brain metastasis still remains largely unknnown. Two melanoma cell lines (opposing phenotypes in ...
ORGANISM(S): Homo sapiens 
2014-02-26 | E-MTAB-2065 | biostudies-arrayexpress
TranscriptomicsAffymetrix expression array data for melanoma progression to the brain
Melanoma is one of the most aggressive and treatment-resistant cancers. It represents the most life-threatening neoplasm of the skin, and its incidence has been increasing for the last three decades. Melanoma evolves from the local transformation of melanocytes to primary tumors, which can metastasi...
ORGANISM(S): Homo sapiens 
2013-09-19 | E-GEOD-44660 | biostudies-arrayexpress
TranscriptomicsWhole Genome Characterization of Circulating Tumor Cells Identifies Novel Prognostic Genomic Alterations in Melanoma Metastasis
Circulating tumor cells (CTCs) are critical in the development of distant organ tumor metastasis, and are associated with advanced cancer stage and poor patient outcome. Here, we present the first genome-wide nucleotide-level characterization of CTCs. Our single-nucleotide polymorphism (SNP) analysi...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-43934 | biostudies-arrayexpress
GenomicsAnalysis of paired primary and metastatic cell lines identifies common DNA methylation changes in melanoma metastasis.
Using 1 melanocyte and 6 melanoma cell line (3 pair of primary and metastatic), we generated base-resolution DNA methylation maps to document DNA methylation drivers of melanoma metastasis. Here we generated single-nucleotide resoultion DNA methylation map of a total of 7 cell lines using Reduced Re...
ORGANISM(S): Homo sapiens 
2017-05-17 | E-GEOD-70621 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human tissue samples to identify novel genes associated with malignant melanoma but not benign melanocytic lesions
A number of melanoma specific genes were identified to differentiate clinical relevant tissue samples containing benign from malignant melanocytes. Experiment Overall Design: 7 normal skin, 18 nevi and 45 melanoma samples
ORGANISM(S): Homo sapiens 
2007-09-06 | E-GEOD-3189 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of 9 pairs of human metastasis/primary melanoma (each from the same patient)
Study by dye-swap of 9 pairs of metastasis/primary melanoma (each from the same patient)
ORGANISM(S): Homo sapiens 
2007-04-01 | E-TABM-4 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of enforced HOXA1 expression in melanoma cell line
We recently reported an oncogenomics-guided screening approach designed to identify genetic drivers of early stage melanoma metastasis, and in this study we functionally validate the top-scoring candidate, homeobox transcription factor A1 (HOXA1), by demonstrating HOXA1‘s robust effects on melanom...
ORGANISM(S): Homo sapiens 
2013-01-08 | E-GEOD-37136 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of enforced HOXA1 expression in melanoma cell line (SkMel30)
We recently reported an oncogenomics-guided screening approach designed to identify genetic drivers of early stage melanoma metastasis, and in this study we functionally validate the top-scoring candidate, homeobox transcription factor A1 (HOXA1), by demonstrating HOXA1 robust effects on melanoma ce...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-40422 | biostudies-arrayexpress
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