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TranscriptomicsNF1 microdeletions characterization by custom high-resolution array CGH
To allow accute charaterization of NF1 locus constitutional microdeletion in 70 NF1 patients, a custom array CGH was developped. Goal was to obtain genomic rearrangements fine characterization in order to perform genotype-phenotype correlation in NF1 microdeleted patients. To serve as a reference g...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-19730 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila infected with Drosophila C virus reveals a third evolutionary conserved innate immunity pathway operates in drosophila and counters viral infection
The response of drosophila to bacterial and fungal infections involves two signaling pathways, Toll and Imd, which both activate NF-kB family members. We have studied the global transcriptional response of flies to infection with drosophila C virus. Viral infection induced a set of genes distinct fr...
ORGANISM(S): Drosophila melanogaster 
2007-07-07 | E-GEOD-2828 | biostudies-arrayexpress
UnknownUnravelling the genetic basis of variable clinical expression in neurofibromatosis 1.
Not available
S-EPMC2722187 | biostudies-literature
TranscriptomicsAnkrd2 silencing
CHQ5B primary human myoblasts obtained from Dr V. Mouly (Paris, France) have been described previously (Faulkner et al., 1999). Ankrd2 is upregulated on differentiation of myoblasts. The change in gene expression was studied in cells silenced for Ankrd2 (infected with AAV-shAnkrd2), control cells (i...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-MEXP-2949 | biostudies-arrayexpress
GenomicsLow frequency and rare coding variation contributes to multiple sclerosis risk
Multiple sclerosis is a common, complex neurological disease, where almost 20% of risk heritability can be attributed to common genetic variants, including >230 identified by genome-wide association studies. Multiple strands of evidence suggest that the majority of the remaining heritability is also...
EGAS00001003195 | EGA
ProteomicsEicosadomics, proteomics and metabolomics of inflammatory stimulated human fibroblasts reveals specific functions related to chronic inflammation - secreted proteins of untreated cells
Fibroblasts have only recently been identified as important effector cells in inflammation. In this study, human dermal fibroblasts were inflammatory stimulated with interleukin-1beta and comprehensively analysed with respect to proteins, eicosanoids and metabolites. For eicosadomics, we have establ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-16 | MSV000080642 | MassIVE
ProteomicsEicosadomics, proteomics and metabolomics of inflammatory stimulated human fibroblasts reveals specific functions related to chronic inflammation - secreted proteins of dexamethasone-treated inflammatory stimulated cells
Fibroblasts have only recently been identified as important effector cells in inflammation. In this study, human dermal fibroblasts were inflammatory stimulated with interleukin-1beta and comprehensively analysed with respect to proteins, eicosanoids and metabolites. For eicosadomics, we have establ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-16 | MSV000080640 | MassIVE
TranscriptomicsTranscription profiling of non-small cell lung carcinoma cell line H1975 treated with cisplatin or BMS-69014 a novel panHER/VEGFR inhibitor
Non-small cell lung cancer (NSCLC) with activating mutations in the epidermal growth factor receptor (EGFR) responds to EGFR tyrosine kinase inhibitors such as erlotinib. However, secondary somatic EGFR mutations (e.g. T790M) confer resistance to erlotinib. BMS-690514, a novel panHER/VEGFR inhibitor...
ORGANISM(S): Homo sapiens 
2007-07-24 | E-TABM-239 | biostudies-arrayexpress
MetabolomicsUnravelling age-driven molecular transitions underlying Pacific Oyster Mortality Syndrome permissiveness in Magallana gigas

Ageing is a progressive and irreversible biological process characterized by the deterioration of physiological functions and increased vulnerability to mortality. Although extensively studied in vertebrates, ageing in long-lived invertebrates remains comparatively unexplored. While ageing typica...

2025-12-08 | MTBLS13463 | MetaboLights
UnknownSevere Phenotype in Patients with Large Deletions of NF1.
Not available
S-EPMC8231977 | biostudies-literature
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