Membrane attack complex

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CHEBI ID

CHEBI:71847 (1)
CHEBI:156118 (1)
CHEBI:71750 (1)
CHEBI:71749 (1)
CHEBI:71743 (1)
CHEBI:134435 (1)
CHEBI:136196 (1)
CHEBI:66865 (1)
CHEBI:66860 (1)
CHEBI:134648 (1)
CHEBI:71712 (1)
CHEBI:156044 (1)
CHEBI:134270 (1)
CHEBI:71731 (1)
CHEBI:64424 (1)
CHEBI:85700 (1)
CHEBI:71736 (1)
CHEBI:71735 (1)
CHEBI:71734 (1)
CHEBI:66859 (1)
CHEBI:64423 (1)
CHEBI:64517 (1)
CHEBI:66849 (1)
CHEBI:66850 (1)

Metabolite Name

4-Hydroxycyclohexylcarboxylic acid (2)
2,3,4,5-Tetrahydro-2-pyridinecarboxylic acid (2)
Demethylphylloquinone (2)
2-Ethyl-1-hexanol sulfate (2)
N-{(2R)-2-Hydroxy-2-[(8S,11S)-8-isopropyl-6,9-dioxo-2-oxa-7,10-diazabicyclo[11.2.2]heptadeca-1(15),13,16-trien-11-YL]ethyl}-N-isopentylbenzenesulfonamide (2)
5-Amino-6-ribitylamino uracil (2)
2-Hydroxybenzaldehyde (2)
Picrocrocin (2)
Indole-3-carbinol (2)
Lauroyl diethanolamide (2)
(R)-Sulcatol (2)
Pentoxifylline (2)
Pterostilbene (2)
Procarbazine (2)
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (2)
5-Phenyl-1,3-oxazinane-2,4-dione (2)
Dodecanoic acid (2)
L-Phenylalanine (2)
BiotinylPE(28:2) (1)
C00049 (1)
PE-NMe (44:4) (1)
PE-NMe(42:4) (1)
Phosphatidylinositol (P-36:5) (1)
Ganglioside GM3 (36:2) (1)
Phosphatidic acid (P-36:3) (1)
Cardiolipin 78:13(2-) (1)
Cardiolipin 78:11(2-) (1)
CL(79:2) (1)
Phosphatidylethanolamine 40:3 zwitterion (1)
Phosphatidylethanolamine 36:5 zwitterion (1)

First Public Date

2026 (4)
2023 (3)
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2024 (2)
2021 (2)
2014 (2)
2022 (1)
2020 (1)
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2018 (1)
2015 (1)

Study type

Transcription profiling by array (172)
RNA-seq of coding RNA (46)
RNA-seq of non coding RNA (20)
ChIP-seq (17)
Other (12)
Methylation profiling by array (8)
RNA-seq of coding RNA from single cells (5)
Unknown experiment type (4)
ChIP-chip by tiling array (4)
ChIP-chip by array (4)
DNA-seq (4)
RNA-seq of total RNA (4)
Transcription profiling by tiling array (3)
Comparative genomic hybridization by array (3)
Proteomic profiling by array (3)
Human - High-throughput sequencing (2)
Animal - High-throughput sequencing (2)
Cell line - High-throughput sequencing (2)
MicroRNA profiling by high throughput sequencing (2)
ATAC-seq (2)
Methylation profiling by high throughput sequencing (2)
Cell line - One-color microarray (1)
Whole chromosome random sequencing (1)
CLIP-seq (1)
Hi-C (1)
Ribo-seq (1)
Genotyping by high throughput sequencing (1)

Release Date

2014 (54)
2023 (47)
2020 (45)
2015 (44)
2021 (42)
2022 (41)
2010 (41)
2025 (40)
2013 (40)
2018 (39)
2011 (39)
2016 (38)
2008 (38)
2012 (37)
2024 (31)
2009 (27)
2019 (25)
2007 (18)
2017 (16)
2006 (10)
2004 (9)
2026 (7)
2005 (2)
2003 (2)
2001 (2)
2000 (2)
1997 (2)

Lab affiliation

Discovery Analytical, GSK, Upper Providence, USA (1)
Institut für Mikrobiologie Dept. Mikrobielle Proteomik Universität Greifswald Felix-Hausdorff-Str. 8 17489 Greifswald (1)
Proteomics Platform CIC bioGUNE Bizkaia Tech. Park Build. 800 48160 Derio (Spain) (1)
Technical University of Munich, Department of Chemistry, Chair of Organic Chemistry II, Lichtenbergstraße 4, 85748 Garching, Germany (1)
Toulouse Institute for infectious and inflammatory diseases (Infinity), University of Toulouse, CNRS, INSERM, UPS, Toulouse, France. Department of Immunology, Toulouse University Hospitals, Toulouse, France. (1)
University Medical Center Hamburg-Eppendorf KöR Center of Diagnostics Section Mass Spectrometry and Proteomics / Core Facility Mass Spectrometric Proteomics (1)

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Sublytic membrane attack complex drives glycolysis and mitochondrial dysfunction with inflammatory consequences in human monocyte-derived macrophages

Not available

ORGANISM(S): Homo sapiens

ST001922 | MetabolomicsWorkbench

Sublytic membrane attack complex drives glycolysis and mitochondrial dysfunction with inflammatory consequences in human monocyte-derived macrophages

The terminal stage of the complement activation pathways, the membrane attack complex (MAC), is upregulated in diabetic and rheumatoid arthritis patients, contributing pathologically by increasing inflammation. Previous research has highlighted that a sublytic dose of MAC can initiate NLRP3 inflamma...

ORGANISM(S): Homo sapiens (Human)

2023-03-11 | PXD027316 | Pride