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TranscriptomicsAscites enriches for ovarian cancer stem-like cells that express membrane GRP78
Ovarian cancer patients are generally diagnosed at stage III/IV, when ascites is common. The volume of ascites positively correlates with the extent of metastasis and negatively with prognosis. Membrane GRP78, a stress-inducible endoplasmic reticulum chaperone which also appears on the plasma membra...
ORGANISM(S): Mus musculus 
2015-03-09 | E-GEOD-61285 | biostudies-arrayexpress
MetabolomicsMelatonin enhances function of porcine immature Sertoli cells via modulating gene expression and metabolism

Melatonin (MT), a neurohormone synthesized and secreted primarily by the pineal gland, is of vital function to animal reproduction. However, the effect of MT treatment on porcine immature Sertoli cells (iSCs) remains unclear. Here, MT treatment (10 nM, 36 h) could elevate mitochondrial function a...

2025-01-06 | MTBLS11126 | MetaboLights
TranscriptomicsTranscription profiling of mouse preshocked hsp70(-/-) and (+/+) cells to assess thermotolerance
From preliminary experiments, HSP70 deficient MEF cells display moderate thermotolerance to a severe heatshock of 45.5 degrees after a mild preshock at 43 degrees, even in the absence of hsp70 protein. We would like to determine which genes in these cells are being activated to account for this ther...
ORGANISM(S): Mus musculus 
2009-04-17 | E-GEOD-11120 | biostudies-arrayexpress
TranscriptomicsThe impact of the HSPA2 gene knockout on transcriptome profile in immortalized epidermal keratinocytes (HaCaT line)
The specific functional features of the epidermal keratinocytes are determined by the activity of many genes. The aim of the project was to characterize the role of HSPA2, a member of the HSPA chaperone family (HSP70), in human epidermal keratinocytes. The inactivation of the HSPA2 gene in the HaCaT...
ORGANISM(S): Homo sapiens 
2023-09-25 | E-MTAB-13166 | biostudies-arrayexpress
UnknownA Low Membrane Hsp70 Expression in Tumor Cells With Impaired Lactate Metabolism Mediates Radiosensitization by NVP-AUY922.
Not available
S-EPMC9022188 | biostudies-literature
UnknownCAR T Cells Targeting Membrane-Bound Hsp70 on Tumor Cells Mimic Hsp70-Primed NK Cells.
Not available
S-EPMC9198541 | biostudies-literature
UnknownAn Aquareovirus Exploits Membrane-Anchored HSP70 To Promote Viral Entry.
Not available
S-EPMC10269764 | biostudies-literature
TranscriptomicsThe impact of the HSPA2 gene downregulation on transcriptome profile in immortalized epidermal keratinocytes (HaCaT line) grown in 3D cell culture
The specific functional features of the epidermal keratinocytes are determined by the activity of many genes. The aim of the project was to characterize the role of HSPA2, a member of the HSPA chaperone family (HSP70), in human epidermal keratinocytes. The downregulation of HSPA2 gene in HaCaT cell ...
ORGANISM(S): Homo sapiens 
2023-11-29 | E-MTAB-13266 | biostudies-arrayexpress
TranscriptomicsExpression data from normal and MDS erythroids cell cutlures ex vivo
CD34 positive cells of bone marrow samples from normal and MDS samples were cultured ex vivo into erythroid conditions. We used microarrays to detail the gene expression programm of erythroid cells between normal and pathological (MDS) samples Mononuclear cells from bone marrow samples were selected...
ORGANISM(S): Homo sapiens 
2012-02-14 | E-GEOD-34268 | biostudies-arrayexpress
UnknownLysosomal exocytosis of HSP70 stimulates monocytic BMP6 expression in Sjogren's syndrome.
Not available
S-EPMC8920330 | biostudies-literature
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