Memory cd4+ t cells

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Unknown (4860)
Genomics (1204)
Transcriptomics (869)
Other (43)
Proteomics (30)
Methylation profiling (26)
Models (6)
Genomic (5)
Metabolomics (2)

Organisms

Homo sapiens (708)
Mus musculus (404)
Macaca mulatta (25)
Rattus norvegicus (2)
Macaca fascicularis (2)
Macaca nemestrina (2)
synthetic construct (2)
Human immunodeficiency virus 1 (1)
Influenza A virus (A/X-31(H3N2)) (1)
Murinae (1)
gut metagenome (1)
Salmo salar (1)
Ovis aries (1)
Cavia porcellus (1)
Chlorocebus aethiops (1)
Chlorocebus pygerythrus (1)
Danio rerio (1)
HIV-1 group M (1)
Musculus (1)
Sus scrofa (1)
Bos taurus (1)
Cytomegalovirus (1)
Influenza A virus (A/California/07-00002/2009(H1N1)) (1)
Severe acute respiratory syndrome coronavirus 2 (1)

Organisms

Homo sapiens (529)
Mus musculus (358)
Macaca mulatta (16)
Chlorocebus pygerythrus (1)
Cavia porcellus (1)
Chlorocebus aethiops (1)
Musculus (1)
Macaca fascicularis (1)
Mammalia (1)
unidentified (1)
Rattus norvegicus (1)
Danio rerio (1)

Repository

ENA (1033)
geo (778)
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EGA (75)
pride (25)
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Tissue

T cell (13)
Blood (7)
Cell culture (4)
B cell (3)
Blood cell (3)
Blood plasma (3)
Brain (2)
Primary cell (2)
Thymus (2)
CD4-positive helper T cell (1)
Cerebral cortex glial cell (1)
Cytotoxic T-lymphocyte protein 4 (mouse) (1)
Dendritic cell (1)
Lymph node (1)
MEF cell (1)
MRC-5 cell (1)
PBMC cell line (1)
Peripheral blood mononuclear cell (1)
Regulatory T cell (1)
Spleen (1)
Umbilical cord blood (1)

Disease

Disease free (3)
Influenza (2)
Multiple sclerosis (2)
Normal (1)
Not Available (1)
Brain glioblastoma multiforme (1)
Human immunodeficiency virus infectious disease (1)
Multiple myeloma (1)
Type 2 diabetes mellitus (1)

Technology Type

Mass Spectrometry (25)
Shotgun proteomics (11)
Bottom-up proteomics (6)
Data-dependent acquisition (4)
Affinity purification coupled with mass spectrometry proteomics (3)
Data-independent acquisition (3)
Immunopeptidomics (2)
Top-down proteomics (2)
ILLUMINA, Illumina HiSeq 2000 (1)
Illumina HiSeq 2000 (1)
Illumina HiSeq 2000, Illumina Genome Analyzer II (1)
Illumina HiSeq 2500, ILLUMINA (1)
Mass spectrometry (1)
Mass spectrometry assay (1)
SWATH MS (1)

Instrument Platform

Illumina NovaSeq 6000 (14)
Illumina HiSeq 2500 (9)
Illumina HiSeq 4000 (6)
NextSeq 500 (6)
NextSeq 550 (3)
Illumina HiSeq 2000 (3)
GeneChip Scanner 3000 7G (2)
Illumina HiSeq 3000 (2)
HPC cluster Lobo (1)
BD FACSAria™ III (1)
Chromium Controller (10X Genomics) (1)
Illumina iScan microarray scanner (1)
Local workstation (1)
Chromium Single Cell 5' Library & Gel Bead Kit v2 (1)
FLOQSwab (Copan) (1)
Agilent Surescan High Resolution DNA microarray Scanner (1)
Beckman Coulter MoFlo Astrios (1)
Agilent G2565CA microarray scanner (1)
Fluidigm C1 (1)
Illumina iScan (1)
Agilent Surescan High Resolution DNA Microarray Scanner (1)
Illumina Genome Analyzer II (1)
NextSeq 1000 (1)
Illumina NovaSeq X (1)
Illumina Stranded Total RNA Prep (1)
RNeasy Micro Kit (Qiagen) (1)
FACSAria II (1)
NA (1)
10x Genomics Chromium Controller (1)
Ion Torrent Proton (1)

Publication Date

2025 (139)
2026 (127)
2022 (92)
2024 (87)
2023 (83)
2021 (69)
2015 (68)
2016 (55)
2019 (52)
2014 (47)
2020 (42)
2013 (41)
2018 (36)
2017 (26)
2011 (24)
2012 (22)
2010 (19)
2008 (17)
2009 (14)
2007 (6)
2005 (1)
2006 (1)
2004 (1)

Metabolite Name

(+)-Cloprostenol methyl amide (1)
(+)-Penbutolol (1)
(1-((1-Methylpiperidin-2-yl)methyl)-1H-indol-3-yl)(naphthalen-1-yl)methanone (1)
(1-(4-Cyanobutyl)-3-(naphthalen-1-oyl)indole) (1)
(1R,3S,4S,6R)-6,9-Dihydroxyfenchone 6-O-b-D-glucoside (1)
(1R,3S,6S,7E,13S,16R,17R,21S,22S)-17-[(2R,4R,5S,6R)-5-[(2S,4R,5S,6R)-4,5-dihydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyloxan-2-yl]oxy-28-hydroxy-3,22-dimethyl-23,26-dioxo-24,27-dioxapentacyclo[23.2.1.01,6.013,22.016,21]octacosa-4,7,14,25(28)-tetraene-4-carboxylic acid (1)
(1R,6S)-6-amino-5-oxocyclohexyl-2-ene-1-carboxylic-acid-ester (1)
(2R)-2-[[4-(2,6-dipyrrolidin-1-ylpyrimidin-4-yl)piperazin-1-yl]methyl]-2,5,7,8-tetramethyl-3,4-dihydrochromen-6-ol;dihydrochloride (1)
(2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(1R,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide (1)
(2S,3S)-butane-2,3-diol (1)
(2r)-3-(Hexadecyloxy)-2-methoxypropyl 2-(trimethylammonio)ethyl phosphate (1)
(2xi,3xi,6E)-3,7-Dimethyl-6-octene-1,2,3,8-tetrol (1)
(5Z,13E)-(15S)-6,9alpha-Epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate (1)
(5Z,7E,9E,14Z,17Z)-Eicosapentaenoic acid (1)
(8E,10Z,13Z,16Z,19Z)-7-hydroxydocosa-8,10,13,16,19-pentaenoic Acid (1)
(8S,10R,13S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one (1)
(E)-Guggulsterone (1)
(E,Z)-2-Amino-3,14-octadecadien-1-ol (1)
(R)-(-)-1-Amino-2-propanol (1)
(R)-(-)-2-phenylglycine (1)
(R)-10-hydroxystearic acid (1)
(R)-2-Hydroxy-3-phenylpropionic acid (1)
(S)-2-acetamido-4-methyl-N-((S)-4-methyl-1-oxo-1-(((R)-1-oxohexan-2-yl)amino)pentan-2-yl)pentanamide (1)
(S)-7-(((2-O-6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one (1)
(S)-[2,8-bis(trifluoromethyl)quinolin-4-yl]-piperidin-2-ylmethanol (1)
(Z)-1-(Methylthio)-5-phenyl-1-penten-3-yne (1)
(all-E)-6'-Apo-y-caroten-6'-al (1)
1,2-Dimyristoyl-sn-glycero-3-phospho-l-serine (1)
1,2-Dimyristoyl-sn-glycero-3-phosphocholine (1)
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (1)

IsPrivate

False (5)

Submitter Keywords

Immuno-oncology (2)

First Public Date

2025 (145)
2026 (130)
2024 (124)
2023 (122)
2022 (99)
2014 (89)
2021 (85)
2019 (58)
2020 (57)
2018 (38)
2017 (32)
2015 (25)
2016 (21)
2013 (8)

Modelling Approach

Ordinary differential equation model (4)

Study type

Transcription profiling by array (146)
RNA-seq of coding RNA (42)
RNA-seq of coding RNA from single cells (18)
ChIP-seq (13)
Transcription profiling by RT-PCR (4)
Methylation profiling by array (4)
Animal - Single-cell sequencing (3)
Other (3)
Animal - One-color microarray (2)
Human - High-throughput sequencing (2)
Animal - High-throughput sequencing (2)
Methylation profiling by high throughput sequencing (2)
Transcription profiling by SAGE (1)
Unknown experiment type (1)
Differential (1)
MeDIP-seq (1)
Human - Single-cell sequencing (1)
Human - One-color microarray (1)
MicroRNA profiling by high throughput sequencing (1)
Comparative genomic hybridization by array (1)
MicroRNA profiling by array (1)
DNA-seq (1)
RNA-seq of total RNA (1)
RNA-seq of non coding RNA (1)

Release Date

2022 (719)
2023 (537)
2021 (533)
2025 (503)
2024 (457)
2020 (371)
2019 (278)
2018 (239)
2016 (226)
2017 (213)
2015 (211)
2014 (161)
2013 (134)
2012 (103)
2011 (103)
2026 (80)
2010 (68)
2009 (61)
2008 (46)
2007 (21)
2006 (17)
2005 (10)
2001 (5)
2004 (3)
2003 (3)
2002 (3)
2000 (3)
1998 (3)
1999 (2)

Lab affiliation

Departments of Chemical and Biological Engineering, Chemistry, and Molecular Biosciences, the Chemistry of Life Processes Institute, and the Proteomics Center of Excellence, Northwestern University, Evanston, Illinois 60208, United States (2)
University of Oxford University of Dundee (2)
1Departments of Medicine & 2Pathology, Case Western Reserve University and University Hospitals Case Medical Center; 3Department of Molecular Biology & Microbiology Case Western Reserve University School of Medicine, Cleveland, Ohio 44106,USA. (1)
Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford; Oxford, U.K.; 3MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford; Oxford, U.K. (1)
Department of Diagnostic Sciences, Ghent University, Ghent, Belgium. Cancer Research Institute Ghent (CRIG), Ghent, Belgium. (1)
Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany (1)
Discovery Proteomics Facility, University of Oxford (1)
Division of Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Campus Solna, 17165 Stockholm, Sweden (1)
Head Proteomics Group Leiden University Medical Center, Center for Proteomics and Metabolomics, PO Box 9600, Postal zone P1-Q, 2300 RC Leiden, The Netherlands (1)
Institute for Research in Biomedicine Università della Svizzera italiana (USI), Faculty of Biomedical Sciences Via Vincenzo Vela 6 6500 Bellinzona, Switzerland (1)
Institute of Cancer Research, London & Wellcome Trust Sanger Institute, Cambridge (1)
Institute of Cerebrovascular Diseases Research, Xuanwu Hospital of Capital Medical University, Beijing, China (1)
Instituto de Investigaciones Sanitarias de Santiago de Compostela (1)
Johns Hopkins University (1)
Mass Spectrometry & Proteomics Core Facility (MSPCF) Institute for Research in Biomedicine (IRB Barcelona) Barcelona Institute of Science and Technology (BIST) C/ Baldiri Reixac, 10-12 08028 Barcelona - Spain (1)
Neuroimmunology and MS Research Section (NIMS), Neurology Clinic, University of Zurich, University Hospital Zurich, 8091 Zurich, Switzerland (1)
Neuroimmunology and MS Research, Neurology Clinic, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland (1)
Precision and Systems Biomedicine Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia (1)
Professor of Chemical Physiology and Biochemistry, School of Medicine OHSU Knight Cancer Institute, School of Medicine (1)
School of Life Sciences, University of Dundee, Dundee, UK(lab head) (1)
Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, USA (1)
University of Tübingen Interfaculty Institute for Cell Biology Department of Immunology Auf der Morgenstelle 15 72076 Tuebingen Germany (1)
as before (1)

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Molecular reprogramming of primary human resting memory CD4+ T cells by HIV-1 Vpr

Resting CD4+ T cells are infected by HIV-1 in vivo, however are refractory to cell-free HIV-1 infection in vitro. We show that they are efficiently infected by cell-to-cell spread. To allow resting T cell infection, uninfected resting target cells were co-cultured with infected donor T cells. Cells ...

ORGANISM(S): Homo sapiens

2022-03-31 | E-MTAB-11454 | biostudies-arrayexpress

Generation and purification of Th1 and Th2 effector and memory CD4+ T cells

NaÃ¯ve CD4+ T cells were isolated from spleen of AND TcR transgenic/green fluorescence protein (GFP) transgenic mice (Kaye et al., Nature 1989;341:746, Wright et al, Blood 2001;97:2278) that recognize a peptide of pigeon cytochrome C in the context of I-Ek and express CD44lo, CD62Lhi, CD45RBhi, and ...

ORGANISM(S): Mus musculus

2010-06-10 | E-GEOD-8352 | biostudies-arrayexpress

DNA methylation profiling of primary human CD4+T-cell memory subsets

Differentiation of CD4+T-cells into effector subsets is a critical component of the adaptive immune system and an incorrect response can lead to autoimmunity or immune deficiency. Cellular differentiation including T-cell differentiation is accompanied by large-scale epigenetic remodeling, including...

ORGANISM(S): Homo sapiens

2016-07-11 | E-MTAB-4689 | biostudies-arrayexpress

Expression data from virus-specific mouse Th1 and Tfh CD4 T cell subsets after LCMV infection

CD4 T follicular helper (Tfh) cells provide the required signals to B cells for germinal center reactions that are necessary for longlived antibody responses. However, it remains unclear whether there are CD4+ memory T cells committed to the Tfh lineage after antigen clearance. Using adoptive transf...

ORGANISM(S): Mus musculus

2013-04-22 | E-GEOD-43863 | biostudies-arrayexpress

Expression data from WT and IL-2 secondary CD4 T cell effectors responding towards infuenza A virus infection

How IL-2 produced by secondary CD4 T cell effectors, derived from resting memory cells, impacts memory CD4 T cell function and survival to memory following antigen re-encounter is unknown. We used microarrays to detail the global programme of gene expression underlying differences between WT and IL-...

ORGANISM(S): Mus musculus

2015-05-14 | E-GEOD-60186 | biostudies-arrayexpress

A Multi-Omic Analysis of Human Naive CD4 T cells

Technological advances in genomics, epigenomics, transcriptomics and proteomics have enabled massively parallel measurements across thousands of genes and gene products. Such high-throughput technologies have been extensively used to carry out genome-wide studies particularly in the context of disea...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2016-04-04 | MSV000079624 | MassIVE

Transcription profiling of mouse RAG1 knockout CD4+ T cells to investigate the effect of absence of interaction with MHC class II on memory CD4 T cells

Effect of absence of interaction with MHC class II on memory CD4 T cells

ORGANISM(S): Mus musculus

2007-03-01 | E-MEXP-890 | biostudies-arrayexpress

Transcription profiling of human CD4+T-cells, Th1/Th2 polarized time-series and primary memory subsets

ORGANISM(S): Homo sapiens

2016-07-11 | E-MTAB-4687 | biostudies-arrayexpress

Generating mouse model with predominant naÃ¯ve or innate memory phenotype CD4+ T cells

Innate memory phenotype (IMP) CD4+ T cells are non-conventional Î±Î² T cells exhibiting features of innate immune cells, characterized as CD44high and CD62Llow in periphery. It is recently reported by our group that bone marrow chimeric mice lacking thymic MHCI expression develop predominantly IMP C...

ORGANISM(S): Mus musculus

2014-03-14 | E-GEOD-46892 | biostudies-arrayexpress

RNA-Seq of mouse CD4+ T cells to analyse CD4+ TERM cells

Transcriptional profiles of naive, memory and TERM (early responder memory T cells) CD4+ T cells from control and LCMV memory mice.

ORGANISM(S): Mus musculus

2024-05-27 | E-MTAB-11521 | biostudies-arrayexpress

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