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ProteomicsQuieting the Storm: Hypoxia as a Strategy to Boost UC-MSC Therapies for Hypoxic-Ischemic Brain Lesions in Neonatal Rats
Integrating stem cell therapies into clinical settings faces several challenges, particularly in achieving the high cell yields necessary for attaining therapeutic doses. Preconditioning with hypoxic conditions has shown promise in enhancing the mesenchymal stem cells (MSCs)’ reparative capabilities...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-04-27 | PXD060639 | Pride
Mesenchymal stem cell  brain hypoxia  cell therapy  hypoxic ischemic encephalopathy  preconditioning  proteomics 
ProteomicsCOVID-19 salivary protein profile: unravelling molecular aspects of SARS-COV-2 infection
COVID-19 is the most impacting global pandemic of all times with over 600 million infected and 6.5 million deaths worldwide, in addition to an unprecedented economic impact. Despite the many advances in scientific knowledge about the disease, much remains to be clarified about the molecular alterati...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD036571 | Pride
Covid-19  saliva  proteomics  interactomics  oralint 
ProteomicsProteome-wide analysis of heat-stress in Pinus radiata somatic embryos reveals a combined response of sugar metabolism and translational regulation mechanisms
Recent research has demonstrated that high temperatures during initial stages of conifer somatic embryogenesis can modulate the subsequent phases of the process, as well as the behaviour of the resulting plants ex vitro. In this sense, the development of high-throughput techniques has facilitated th...
ORGANISM(S): Pinus radiata (Monterey pine) 
2021-04-09 | PXD022711 | Pride
Carbohydrates Proteomics Heat shock proteins Methylation Compatible solutes Somatic embryogenesis. High temperatures Radiata pine 
ProteomicsDeciphering Early Pathogenic Changes in Alzheimer's disease
The aim of the present project is to detect biochemical alterations that can pinpoint specific pathogenic processes at early phases of AD, evaluated in the cerebrospinal fluid, that more closely reflect the pathogenic processes in the brain, and independently of whether an amyloid response was trigg...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD039563 | Pride
Alzheimer's disease  cerebral spinal fluid proteomics 
ProteomicsThe Secretome of Macrophages Has a Differential Impact on Spinal Cord Injury Recovery According to the Polarization Protocol
The inflammatory response after spinal cord injury (SCI) is an important contributor to secondary damage. Infiltrating macrophages can acquire a spectrum of activation states, however, the microenvironment at the SCI site favors macrophage polarization into a pro-inflammatory phenotype, which is one...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-14 | PXD048453 | Pride
Spinal cord injury  macrophages  secretome  proteomics Lc-ms/ms 
UnknownElective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.
Not available
S-EPMC8189635 | biostudies-literature
UnknownEpidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study.
Not available
S-EPMC9916499 | biostudies-literature
UnknownStudy protocol for the multicentre cohorts of Zika virus infection in pregnant women, infants, and acute clinical cases in Latin America and the Caribbean: the ZIKAlliance consortium.
Not available
S-EPMC6933915 | biostudies-literature
UnknownEvaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries.
Not available
S-EPMC10771257 | biostudies-literature
UnknownPresentation, management, and outcomes of older compared to younger adults with hospital-acquired bloodstream infections in the intensive care unit: a multicenter cohort study.
Not available
S-EPMC11621140 | biostudies-literature
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