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Transcriptomicsp53 amplifies Toll-like receptor 5 response in MCF-7 cells
Using gene expression profiling we characterize the global effect of p53 on the TLR5-mediated transcription in MCF7 cells. We found that combined activation of p53 and TLR5 pathways synergistically increases expression of over 200 genes, mostly associated with immunity and inflammation. The synergy ...
ORGANISM(S): Homo sapiens 
2015-08-26 | E-GEOD-72359 | biostudies-arrayexpress
TranscriptomicsDiverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells (Affymetrix)
The effects of diverse stresses on promoter selectivity and transcription regulation by the tumor suppressor p53 are poorly understood. We have taken a comprehensive approach to characterizing the human p53 network that includes p53 levels, binding, expression and chromatin changes under diverse str...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-46493 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression analysis in macrophages treated with Nutlin-3
The goal of the study is to identify p53 target genes specific to macrophages using the p53 stabilizer, Nutlin-3. Macrophages were differentiated x-vivo from monocytes obtained from healthy volunteers either left untreated or treated for 2 hours with 100 ng/mL of lipopolysaccharide (LPS), 0.1%v/v of...
ORGANISM(S): Homo sapiens 
2014-05-21 | E-GEOD-43596 | biostudies-arrayexpress
UnknownGlobal disparities in surgeons' workloads, academic engagement and rest periods: the on-calL shIft fOr geNEral SurgeonS (LIONESS) study.
Not available
S-EPMC11455666 | biostudies-literature
UnknownGenetic predisposition to in situ and invasive lobular carcinoma of the breast.
Not available
S-EPMC3990493 | biostudies-literature
UnknownGenetic variation in mitotic regulatory pathway genes is associated with breast tumor grade.
Not available
S-EPMC4204763 | biostudies-literature
UnknownEvidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation.
Not available
S-EPMC4321900 | biostudies-literature
UnknownGenome-wide association studies identify four ER negative-specific breast cancer risk loci.
Not available
S-EPMC3771695 | biostudies-literature
UnknownPALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS.
Not available
S-EPMC5200636 | biostudies-literature
UnknownA Type 1 Diabetes Genetic Risk Score Predicts Progression of Islet Autoimmunity and Development of Type 1 Diabetes in Individuals at Risk.
Not available
S-EPMC6105323 | biostudies-literature
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