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TranscriptomicsTLR4 ligands LPS and MPLA differentially regualte effector and memory CD8 T cell differentiation
Here we implemented a simple dendritic cell (DC)-mediated immunization approach to study the effects of commonly used adjuvants, Toll like receptor (TLR) ligands, on effector CD8 T cell differentiation and memory T cell development. To our surprise, we found that the TLR4 ligand LPS was far more sup...
ORGANISM(S): Mus musculus 
2014-06-03 | E-GEOD-50764 | biostudies-arrayexpress
TranscriptomicsCyclin D1 Transgenic Mice with Bim-deficient B-cells
Expression analysis from a genetically engineered mouse model of mantle cell lymphoma (MCL) Gene expression was measured in fourteen mice that overexpress cyclin D1 and delete Bim in their B cells and that were stimulated with sheep red blood cells (SRBC) and irradiation (I), pristane (P) or only SR...
ORGANISM(S): Mus musculus 
2014-02-05 | E-GEOD-52214 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of gene expression of Th1 and Tfh LCMV-specific Smarta CD4 T cell populations
In this study, we sought to distinguish phenotypically and functionally distinct virus-specific effector CD4 T cell subsets that form during acute lymphocytic choriomeningitis virus (LCMV) infection and to examine their ability to develop into memory T cells. To further characterize the effector su...
ORGANISM(S): Mus musculus 
2011-10-04 | E-GEOD-32596 | biostudies-arrayexpress
TranscriptomicsTemporal Response to seasonal and pandemic H1N1 infection in human DCs
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-08-20 | E-GEOD-55278 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of Influenza vaccine response in Young and Old
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-01-27 | E-GEOD-59714 | biostudies-arrayexpress
TranscriptomicsTemporal Response to seasonal and pandemic H1N1 infection in human DCs- Donor 1
An 8 hours timecourse was performed with human DCs infected either with A/California/7/2009 and A/Brevig Mission/1/1918 (pandemic) or A/New Caledonia/20/99 and A/Texas/36/91 seosonal. Human monocyte derived dendritic cells (DCs) were infected either with chicken egg grown A/California/7/2009, A/Br...
ORGANISM(S): Homo sapiens 
2015-08-20 | E-GEOD-55276 | biostudies-arrayexpress
TranscriptomicsTemporal Response to seasonal and pandemic H1N1 infection in human DCs - Donor2
An 8 hours timecourse was performed with human DCs infected either with A/California/7/2009 and A/Brevig Mission/1/1918 (pandemic) or A/New Caledonia/20/99 and A/Texas/36/91 seosonal. Human monocyte derived dendritic cells (DCs) were infected either with chicken egg grown A/California/7/2009, A/Br...
ORGANISM(S): Homo sapiens 
2015-08-20 | E-GEOD-55277 | biostudies-arrayexpress
TranscriptomicsMemory B cell subset defined by CD80 and PD-L2 surface expression
NP-reactive murine splenic memory B cells were sorted based on the expression of the surface markers CD80 and PD-L2 AM14 tg+ X Vk8R+/- recipients of B1-8+ B cells were immunized with NP-CGG and 8 weeks later splenic EMA-, CD19+ and NP+ memory B cells were sorted based on their surface expression of ...
ORGANISM(S): Mus musculus 
2014-05-06 | E-GEOD-51604 | biostudies-arrayexpress
TranscriptomicsSerum predictors of susceptibility to infection with West Nile virus
West Nile virus (WNV) is a mosquito-borne RNA flavivirus and the cause of more than 31,000 cases in the USA from 1999-2011 including 1, 262 fatalities. WNV infections are typically asymptomatic, but some patients, especially the elderly and immunocompromised, may experience severe neurological disea...
ORGANISM(S): Homo sapiens 
2012-12-29 | E-GEOD-43190 | biostudies-arrayexpress
TranscriptomicsProfiling the successful response to infection with West Nile virus
Individual variations in immune status and function determine responses to infection and contribute to disease severity and outcome. Patients exhibit considerable variation in clinical responses to infection with West Nile virus. We have undertaken a comprehensive characterization of the immune resp...
ORGANISM(S): Homo sapiens 
2014-11-24 | E-GEOD-46681 | biostudies-arrayexpress
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