Sort   by:  
 Page size 
ProteomicsCharacterization of progressive denaturation and unfolding intermediates of proteins by fast cross-linking using di-ortho-phthalaldehyde
Chemical cross-linking of proteins coupled with mass spectrometry (CXMS) is widely used in protein structural analysis. In this study we develop a new class of non-hydrolyzable amine-selective di-ortho-phthalaldehyde (DOPA) cross-linkers, one of which is DOPA2. Cross-linking of proteins with DOPA2 i...
ORGANISM(S): Staphylococcus Aureus Bos Taurus 
2021-12-20 | PXD030552 |
ProteomicsChaperonin TRiC bridges radial spokes for folding proteins locally translated in mammalian sperm flagella
As animals evolved from external to internal fertilization, sperm flagella, which once transiently propelled sperm in water to reach nearby eggs, developed to beat for days or even longer within the female reproductive tract. How flagella were remodeled accordingly remains unclear. Unlike externally...
ORGANISM(S): Bos Taurus 
2025-08-12 | PXD067693 |
ProteomicsTargeting vulnerable microcircuit in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss
Background:Episodic memory loss is a prominent clinical manifestation of Alzheimer's disease(AD), which is closely related to tau pathology and hippocampal impairment. Given the heterogeneity of brain neurons, the precise role of different brain neurons in terms of their sensitivity to tau accumulat...
ORGANISM(S): Mus Musculus 
2023-07-19 | PXD043883 |
Sort   by:  
 Page size