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TranscriptomicsExpression profiling of five different xenobiotics using a C. elegans microarray
Using a C. elegans whole genome DNA microarray in this study, the effects of five different xenobiotics on the gene expression of the nematode were investigated. The exposure time for the following five applied compounds beta-NF (5 mg/l), Fla (0.5 mg/l), atrazine (25 mg/l), clofibrate (10 mg/l) and ...
ORGANISM(S): Caenorhabditis elegans 
2006-01-27 | E-GEOD-4111 | biostudies-arrayexpress
TranscriptomicsBeta-naphthoflavone treated worms
The soil nematode Caenorhabditis elegans is one of the simplest animals having the status of a laboratory model. Its genome contains 80 cytochrome P450 genes (CYP). In order to study CYP gene expression in C. elegans mixed stages and synchronized hermaphrodites were exposed to 18 known xenobiotic cy...
ORGANISM(S): Caenorhabditis elegans 
2005-11-25 | E-GEOD-3680 | biostudies-arrayexpress
TranscriptomicsGene expression profiling as a tool for sediment risk assessment: a pilot study using Caenorhabditis elegans whole genome microarrays
Toxicity of river sediments are assessed using whole sediment toxicity tests with benthic organisms. The challenge, however, is the differentiation between multiple effects caused by complex contaminant mixtures and the unspecific toxicity endpoints such as survival, growth or reproduction. Moreover...
ORGANISM(S): Caenorhabditis elegans 
2008-06-25 | E-GEOD-11837 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of C. elegans exposed to quercetin and tannic acid
Recent research has highlighted that the polyphenols Quercetin (Q) and Tannic acid (TA) are capable of extending the lifespan of C. elegans. To gain a deep understanding of the underlying molecular genetics, we analyzed the global transcriptional patterns of nematodes exposed to Quercetin or Tannic ...
ORGANISM(S): Caenorhabditis elegans 
2012-02-03 | E-GEOD-35354 | biostudies-arrayexpress
TranscriptomicsRNA-seq of mitochondrial mass fractions within SCA1+/PDGFRA+/CD31- fibroblasts from adult mouse hearts
In this project we explore the mitochondrial properties of SCA1+/PDGFRA+/CD31- (S+P+) cardiac fibroblasts (CF) from uninjured adult mouse hearts. We fractionated S+P+ cells on the basis of mitochondrial mass using MitoTracker green-FM and flow cytometry into three fractions: high, mid and low mitoch...
ORGANISM(S): Mus musculus 
2021-12-02 | E-MTAB-9675 | biostudies-arrayexpress
TranscriptomicsThe complex interplay of genetic pathways in C.elegans following the treatment with humic substances
Low concentrations of the dissolved leonardite humic acid HuminFeed® (HF) prolonged the lifespan and enhanced the thermal stress resistance of the model organism Caenorhabditis elegans. Furthermore growth was impaired and reproduction delayed, effects which have also been identified in other polyphe...
ORGANISM(S): Caenorhabditis elegans 
2012-02-03 | E-GEOD-35360 | biostudies-arrayexpress
TranscriptomicsExposure of C. elegans to AOBr-containing surface water samples and to a M. aeruginosa batch culture
Elevated levels of adsorbable organic bromine compounds (AOBr) have been detected in German lakes, and cyanobacteria like Microcystis, which are known for the synthesis of microcystins, are one of the main producers of natural organobromines. However, very little is known about how environmental rea...
ORGANISM(S): Caenorhabditis elegans 
2015-05-12 | E-GEOD-68709 | biostudies-arrayexpress
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