Sort   by:  
 Page size 
TranscriptomicsConditional knockdown of DNA methyltransferase-1 (Dnmt1) reveals a key role of retinal pigment epithelium integrity in photoreceptor outer segment morphogenesis
To explore the epigenetic contribution to retinal development, we generated conditional knockout alleles of DNA methytransferase-1 (Dnmt1) mediated by Rx-Cre in mice. The results demonstrate a unique function of DNMT1-mediated DNA methylation in controlling RPE apicobasal polarity and neural retina...
ORGANISM(S): Mus musculus 
2013-01-31 | E-GEOD-43951 | biostudies-arrayexpress
TranscriptomicsA novel methyl-binding domain protein enrichment method for identifying genome-wide tissue-specific DNA methylation from nanogram DNA samples
Growing evidence suggests that DNA methylation plays a role in tissue-specific differentiation. Current approaches to methylome analysis using MBD-enrichment are restricted to large (M-bM-^IM-%1 M-BM-5g) DNA samples, limiting the analysis of small tissue samples. Here we present a technique which en...
ORGANISM(S): Mus musculus 
2013-06-10 | E-GEOD-46683 | biostudies-arrayexpress
Sort   by:  
 Page size