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ProteomicsAn extracellular receptor tyrosine kinase motif orchestrating intracellular STAT activation
The ErbB4 receptor isoforms JM-a and JM-b differ within their extracellular juxtamembrane (eJM) domains. Here, ErbB4 isoforms are used as a model to address the effect of structural variation in the eJM domain of receptor tyrosine kinases (RTK) on downstream signaling. A specific JM-a-like sequence ...
ORGANISM(S): Homo sapiens (Human) 
2023-01-30 | PXD026546 | Pride
Receptor tyrosine kinase Jm-a Rtk Stat signaling Erbb4 Jm-b 
ProteomicsAn extracellular receptor tyrosine kinase motif orchestrating intracellular STAT activation
The ErbB4 receptor isoforms JM-a and JM-b differ within their extracellular juxtamembrane (eJM) domains. Here, ErbB4 isoforms are used as a model to address the effect of structural variation in the eJM domain of receptor tyrosine kinases (RTK) on downstream signaling. A specific JM-a-like sequence ...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) Cercopithecus aethiops (Green monkey) (Grivet) 
2023-01-30 | PXD017783 | Pride
N-lectin Streptavidin pull down 
ProteomicsDe Novo multi-omics pathway analysis (DMPA) designed for prior data independent inference of cell signaling pathways
New tools for cell signaling pathway inference from multi-omics data that are independent of previous knowledge are needed. Here we propose a new de novo method, the de novo multi-omics pathway analysis (DMPA), to model and combine omics data into network modules and pathways. DMPA was validated wit...
ORGANISM(S): Homo sapiens (Human) 
2024-02-21 | PXD046503 | Pride
Multiomics Tyro3 Rtk Gamma-secretase Pathway analysis 
ProteomicsVAV3 in ERBB4-mediated cancer cell migration
ERBB4 is a member of the epidermal growth factor receptor (EGFR)/ERBB subfamily of receptor tyrosine kinases that regulates cellular processes including proliferation, migration and survival. ERBB4 signaling is involved in embryogenesis and homeostasis of adult tissues, but also in human pathologies...
ORGANISM(S): Homo sapiens (Human) 
2020-06-24 | PXD019430 | Pride
Vav3 Targeted analysis Prm Erbb4 
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