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Transcriptomics3' mRNA-seq of neurites and soma isolated from mESC-derived neurons
3' mRNA-seq was performed with QuantSeq 3' mRNA-Seq kit (Lexogen 015) according to the manufacturer’s recommendations. 3' mRNA-seq was done in biological triplicates (soma) or duplicates (neurites), using 260 ng of total RNA from neurites or soma of mESC-derived neurons per sample. Libraries were po...
ORGANISM(S): Mus musculus 
2019-01-12 | E-MTAB-7251 | biostudies-arrayexpress
TranscriptomicsDistinct roles of Tet1 and Tet2 in mouse embryonic stem cells (CMS-Seq)
The TET proteins TET1, TET2 and TET3 constitute a new family of dioxygenases that utilize molecular oxygen and the cofactors Fe(II) and 2-oxoglutarate to convert 5-methylcytosine (5mC) to 5-hydroxy-methylcytosine (5hmC) and further oxidation products in DNA1-5. Here we show that Tet1 and Tet2 have d...
ORGANISM(S): Mus musculus 
2014-01-16 | E-GEOD-50200 | biostudies-arrayexpress
GenomicsTranscriptomic Analysis of Naïve mESC, Primed mESC and EpiLC
Transcriptomic Analysis of Naïve mESC, Primed mESC and EpiLC
PRJNA803231 | ENA
TranscriptomicsRNA-seq of Dand5 KO and WT mESC
DAND5 is an extracellular protein belonging to the family of TGF-β/Nodal signaling antagonists Cerberus/DAN. Loss-of-function of DAND5 in mice leads to a massive increase of the ventricular heart wall’s thickness caused by an increased mitotic index of the CMs at the compact myocardium. To clarify t...
ORGANISM(S): Mus musculus 
2021-03-26 | E-MTAB-9986 | biostudies-arrayexpress
GenomicsK562+mESC bulk RNAseq
bulk RNAseq of K562 and mESC
PRJEB67943 | ENA
TranscriptomicsDistinct roles of Tet1 and Tet2 in mouse embryonic stem cells (RNA-Seq)
The TET proteins TET1, TET2 and TET3 constitute a new family of dioxygenases that utilize molecular oxygen and the cofactors Fe(II) and 2-oxoglutarate to convert 5-methylcytosine (5mC) to 5-hydroxy-methylcytosine (5hmC) and further oxidation products in DNA1-5. Here we show that Tet1 and Tet2 have d...
ORGANISM(S): Mus musculus 
2014-01-16 | E-GEOD-50198 | biostudies-arrayexpress
GenomicsscRNAseq of embryoid bodies derived from control mESC or mESC pulsed with DUX expression
scRNAseq of embryoid bodies derived from control mESC or mESC pulsed with DUX expression
PRJNA627848 | ENA
TranscriptomicsGenome-wide analysis of the transcriptomes of mouse embryonic stem cells (mESC) maintained in different indicated conditions.
Analysis of genes involved in the mESC maintainance between different conditions of growth. The hypothesis tested in the present study was that Myc can sustain mESC self renewal and pluripotency. Results provide important information on the mechanism by which Myc supports mESC self renewal, in compa...
ORGANISM(S): Mus musculus 
2016-03-31 | E-GEOD-58656 | biostudies-arrayexpress
GenomicsK562+mESC Plexwell
Single cell sequencing with Plexwell of K562 and mESC
PRJEB67541 | ENA
TranscriptomicsTranscriptome profiling of severe spinal muscular atrophy mouse embryonic stem cell-derived motor neurons
Proximal spinal muscular atrophy (SMA) is an early onset, autosomal recessive motor neuron disease caused by loss of or mutation in SMN1 (survival motor neuron 1). Despite understanding the genetic basis underlying this disease, it is still not known why motor neurons (MNs) are selectively affected ...
ORGANISM(S): Mus musculus 
2014-09-08 | E-GEOD-56284 | biostudies-arrayexpress
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