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TranscriptomicsDNA methylation in progenitor cells: MeDIP study
We surveyed DNA methylation profiles of all human RefSeq promoters in relation to gene expression and differentiation in adipose tissue, bone marrow and muscle mesenchymal progenitors, as well as in bone marrow-derived hematopoietic progenitors. We unravel strongly overlapping DNA methylation profil...
ORGANISM(S): Homo sapiens 
2010-05-12 | E-GEOD-19794 | biostudies-arrayexpress
GenomicsOverloading mesenchymal progenitors (FAPs)
Overloading mesenchymal progenitors (FAPs)
PRJNA683206 | ENA
GenomicsOverloading mesenchymal progenitors (FAPs)
Overloading mesenchymal progenitors (FAPs)
PRJNA667659 | ENA
ProteomicsSecretome Comparison of Mesenchymal Stromal Cells and Immature Osteoblasts
Osteoblasts are a key component of the endosteal hematopoietic stem cell (HSC) niche and have long been recognized with strong hematopoietic supporting activity. Osteoblast conditioned media (OCM) enhances the growth of hematopoietic progenitors in culture and modulate their engraftment activity. We...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-15 | MSV000088384 | MassIVE
TranscriptomicsCXCL12 Production by Early Mesenchymal Progenitors is Required for Hematopoietic Stem Cell Maintenance
Hematopoietic stem cells (HSCs) primarily reside in the bone marrow where signals generated by stromal cells regulate their self-renewal, proliferation, and trafficking. Endosteal osteoblasts and perivascular stromal cells including endothelial cells3, CXCL12-abundant reticular (CAR) cells, leptin-...
ORGANISM(S): Mus musculus 
2013-01-31 | E-GEOD-43613 | biostudies-arrayexpress
TranscriptomicsChanges of miRNAs during osteogenic differentiation of PDGFRa+ mesenchymal progenitors derived from human skeletal muscle
Comprehensive analyses of miRNAs expression were performed using miRNA microarrays during osteogenic differentiation of PDGFRa+ mesenchymal progenitors isolated from human skeletal muscle to identify miRNAs that are involved in osteogenesis of PDGFRa+ mesenchymal progenitors. PDGFRa+ mesenchymal pro...
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-39361 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Mesenchymal Stem Cells (MSC) vs reference RNA of non-multipotent human fibroblasts HS68
Mesenchymal stem cells (MSC) resemble a multipotent adult stem cell population capable of differentiation into a number of different mesodermal cell types including adipodytes, osteoblasts, chondroblasts. Although still in debate there is some evidence, that these cells can also differentiate into c...
ORGANISM(S): Homo sapiens 
2005-08-23 | E-EMBL-4 | biostudies-arrayexpress
ProteomicsConditioned medium from human iPSC-derived mesenchymal progenitors: Effect of extended progenitor cultivation vs. osteogenic pre-differentiation on the medium stimulatory activity
Human induced pluripotent stem cells provide an unlimited, scalable source of youthful tissue progenitors and secretome for regenerative therapies. The aim of our study was to assess the potential of conditioned medium (CM) derived from hiPSC-mesenchymal progenitors (hiPSC-MPs) to stimulate osteogen...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD052766 | Pride
Human ipscs Osteogenic differentiation Mesenchymal progenitors Proteomic analysis Conditioned medium Human bone marrow mesenchymal stromal cells Secretome Aging 
GenomicsTranscriptional profiling of GFP-Cre–expressing mesenchymal nephron progenitors
Transcriptional profiling of GFP-Cre–expressing mesenchymal nephron progenitors
PRJNA1390601 | ENA
TranscriptomicsA human iPSC model of Hutchinson Gilford Progeria Syndrome reveals a possible mesenchymal stem cell defect
Hutchinson Gilford Progeria Syndrome (HGPS) is a rare, sporadic genetic disease caused by mutations in the nuclear lamin A gene. In most cases the mutation creates an efficient donor-splice site that generates an altered transcript encoding a truncated lamin A protein, progerin. In vitro studies ha...
ORGANISM(S): Homo sapiens 
2010-12-23 | E-GEOD-26093 | biostudies-arrayexpress
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