Sort   by:  
 Page size 
GenomicsBrg1 Modulates Enhancer Activation and Polycomb-mediated Repression in Mesoderm Differentiation [ChIP-exo]
We investigated the genome-wide occupancy changes in normal and Brg1-deleted mesoderm differentiation of mouse embryonic stem cells of chromatin regulators and histone modifications. ChIP exo for BRG1 in 2 conditions: Day4 THF (Control) and Day4 4OHT (Brg1-deleted). 1-2 replicates per condition.
ORGANISM(S): Mus musculus 
2015-03-01 | E-GEOD-63976 | biostudies-arrayexpress
TranscriptomicsThe Polycomb protein Pcgf2/Mel18 regulates mesoderm cell fate-specification of embryonic stem cells through multiple mechanisms
Polycomb complexes are essential regulators of stem cell identity, yet very little is known about their molecular mechanisms during cell differentiation. Pcgf proteins (Pcgf1/2/3/4/5/6) are core subunits of the Polycomb repressive complex 1 (PRC1). It has been recently proposed that specific Pcgf pr...
ORGANISM(S): Mus musculus 
2015-09-04 | E-GEOD-67868 | biostudies-arrayexpress
TranscriptomicsIn vitro cultured H7 human embryonic stem cells (WiCell) and H7-derived downstream early mesoderm progenitors
Stem-cell differentiation to desired lineages requires navigating alternating developmental paths that often lead to unwanted cell types. Hence, comprehensive developmental roadmaps are crucial to channel stem-cell differentiation toward desired fates. To this end, here, we map bifurcating lineage c...
ORGANISM(S): Homo sapiens 
2016-08-02 | E-GEOD-85066 | biostudies-arrayexpress
TranscriptomicsExpression data from undifferentiated human embryonic stem cells (hESC) and Day 3.5 mesodermal progenitor (CD326neg CD56+) population
Our understanding of how mesodermal tissue is formed, has been limited by the absence of specific and reliable markers of early mesoderm commitment. We report that mesoderm commitment from human embryonic stem cells (hESC) is initiated by Epithelial to Mesenchymal transition (EMT) as shown by gene e...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-21668 | biostudies-arrayexpress
TranscriptomicsRNA-seq of wild-type and PGR (progesterone receptor) knockout pluripotent mouse EpiSCs (epiblast stem cells) and differentiated samples derived from these cell lines (primitive streak and mesoderm)
EpiSCs (epiblast stem cells) are murine pluripotent stem cells derived from the epiblast of a post-implantation embryo. These cells are primed to differentiate towards embryonic germ layers and are a useful model to study these early developmental events. PGR (progesterone receptor) is a nuclear rec...
ORGANISM(S): Mus musculus 
2022-11-30 | E-MTAB-12104 | biostudies-arrayexpress
ModelsMbodj2016 - Mesoderm specification during Drosophila development
Mbodj2016 - Mesoderm specification during Drosophila development This model is described in the article: Qualitative Dynamical Modelling Can Formally Explain Mesoderm Specification and Predict Novel Developmental Phenotypes. Mbodj A, Gustafson EH, Ciglar L, Junion G, Gonzale...
2016-10-25 | MODEL1607310000 | BioModels
TranscriptomicsPharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis
The search for developmental mechanisms driving vertebrate organogenesis has paved the way toward a deeper understanding of birth defects. During embryogenesis, parts of the heart and craniofacial muscles arise from pharyngeal mesoderm (PM) progenitors. Here, we reveal a hierarchical regulatory netw...
ORGANISM(S): Mus musculus 
2012-11-26 | E-GEOD-42389 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq of H9 nEnd cells subjected to mesoderm differentiation.
The origin of human extraembryonic mesoderm (ExM) has been heavily debated. In order to address if ExM can be derived from primitive endoderm (PrE), we treated the human PrE cell line (also called na�ve extraembryonic endoderm (nEnd)) with a mesoderm induction protocol and sequenced the entire day 1...
ORGANISM(S): Homo sapiens 
2023-06-29 | E-MTAB-12562 | biostudies-arrayexpress
TranscriptomicsIdentification of TWIST1 transcriptoinal targets in the cranial mesoderm [WNT1 vs. MESP1]
TWIST1, a basic helix-loop-helix transcription factor is essential for the development of cranial mesoderm and cranial neural crest-derived craniofacial structures. Our previous work showed that, in the absence of TWIST1, some cells within the cranial mesoderm adopt an abnormal epithelial configurat...
ORGANISM(S): Mus musculus 
2016-08-23 | E-GEOD-80335 | biostudies-arrayexpress
TranscriptomicsmicroRNA-Seq of Gallus gallus embryo tissues: Undetermined Presomitic Mesoderm (PSM), Determined PSM, and Limb bud
This analysis aims at finding the microRNAs present in three chick embryo undifferentiated tissues (pools of tissues): Undetermined Presomitic Mesoderm (PSM-U), Determined Presomitic Mesoderm (PSM-D) and Distal limb bud (Limb).
ORGANISM(S): Gallus gallus 
2021-10-25 | E-MTAB-8176 | biostudies-arrayexpress
Sort   by:  
 Page size