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TranscriptomicsMicroRNA-150 Contributes to the Proficiency of B-Cell Receptor Signaling in Chronic Lymphocytic Leukemia by Regulating Expression of GAB1 and FOXP1 Genes
We examined the microRNAs (miRNAs) expressed in chronic lymphocytic leukemia (CLL) and identified miR-150 as the most abundant, but with leukemia-cell-expression levels that varied among patients. CLL cells that expressed ZAP-70 or that used unmutated IGHV each had a median expression-level of miR-1...
ORGANISM(S): Homo sapiens 
2014-08-04 | E-GEOD-49896 | biostudies-arrayexpress
TranscriptomicsA macrophage autonomous alpha4beta1integrin-Syk-Rac2 signaling axis controls macrophage differentiation, tumor growth and metastasis
Macrophages, play an essential role in promoting tumor growth by affecting angiogenesis, immune suppression, invasion and metastasis. The signal transduction events within macrophages which encode the complex cascade of events required for tumor growth and polarization of macrophages are poorly unde...
ORGANISM(S): Mus musculus 
2012-10-02 | E-GEOD-41236 | biostudies-arrayexpress
TranscriptomicsA macrophage autonomous α4β1integrin-Syk-Rac2 signaling axis controls macrophage differentiation, tumor growth and metastasis
Macrophages, play an essential role in promoting tumor growth by affecting angiogenesis, immune suppression, invasion and metastasis. The signal transduction events within macrophages which encode the complex cascade of events required for tumor growth and polarization of macrophages are poorly unde...
ORGANISM(S): Mus musculus 
2012-11-15 | E-GEOD-41717 | biostudies-arrayexpress
TranscriptomicsROR1 Can Interact With TCL1 And Enhance Leukemogenesis in EM-BM-5-TCL1 Transgenic Mice
Transcriptome analysis of RNA samples from leukemia cells of ROR1xTCL1 and TCL1 transgenic mice Animals engrafted with ROR1xTCL1 leukemia-cells developed more aggressive disease than mice engrafted with TCL1 leukemia cells. Transcriptome analysis of RNA samples from leukemia ROR1xTCL1 transgenic mi...
ORGANISM(S): Mus musculus 
2014-01-02 | E-GEOD-51420 | biostudies-arrayexpress
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