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TranscriptomicsExpression data from exosomes
Bone marrow (BM) niches provide an optimal substrate for multiple myeloma (MM) cell lodgement and growth. Nevertheless, little is known about the putative mechanisms by which the BM microenvironment can lead to initiation or progression of oncogenesis in this disease. We have demonstrated that BM m...
ORGANISM(S): Homo sapiens 
2013-07-24 | E-GEOD-39571 | biostudies-arrayexpress
TranscriptomicsSynthetic lethality between Rb, p53 and miR-17~92 in retinal progenitors suppresses retinoblastoma formation_murine data
Although Dicer1 functions as a haploinsufficient tumour suppressor its complete loss of function is selected against during tumourigenesis. Here we show that homozygous loss of Dicer1 prevents retinoblastoma formation in mice by synthetic lethality with combined inactivation of the p53 and Rb tumor ...
ORGANISM(S): Mus musculus 
2012-07-05 | E-GEOD-39106 | biostudies-arrayexpress
TranscriptomicsSynthetic lethality between Rb, p53 and miR-17~92 in retinal progenitors suppresses retinoblastoma formation_human data
Although Dicer1 functions as a haploinsufficient tumour suppressor its complete loss of function is selected against during tumourigenesis. Here we show that homozygous loss of Dicer1 prevents retinoblastoma formation in mice by synthetic lethality with combined inactivation of the p53 and Rb tumor ...
ORGANISM(S): Homo sapiens 
2012-07-05 | E-GEOD-39105 | biostudies-arrayexpress
TranscriptomicsSynthetic lethality between Rb, p53 and miR-17~92 in retinal progenitors suppresses retinoblastoma formation
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-07-05 | E-GEOD-39107 | biostudies-arrayexpress
TranscriptomicsLong non-coding RNA expression profiling in the NCI60 cancer cell line panel using high-throughput RT-qPCR
Long non-coding RNAs (lncRNAs) form a new class of RNA molecules implicated in various aspects of protein coding gene expression regulation. To study lncRNAs in cancer, we generated expression profiles for 1708 human lncRNAs in the NCI60 cancer cell line panel using a high-throughput nanowell RT-qPC...
ORGANISM(S): Homo sapiens 
2016-06-29 | E-GEOD-80332 | biostudies-arrayexpress
TranscriptomicsThe role of miRNAs in neuroblastoma tumor development
Neuroblastoma (NB) is an embryonic tumor arising from immature sympathetic nervous system progenitor cells. MYCN and ALK are driver oncogenes both of which are specifically expressed during early neurogenesis. This is in line with the assumption that NB arises through disruption of normal developmen...
ORGANISM(S): Mus musculus 
2014-10-01 | E-MTAB-2618 | biostudies-arrayexpress
TranscriptomicsThe exon junction complex controls transposable element activity by ensuring faithful splicing of the piwi transcript
The exon junction complex (EJC) is a highly conserved ribonucleoprotein complex which binds RNAs during splicing and remains associated with them following export to the cytoplasm. While the role of this complex in mRNA localization, translation and degradation has been well characterized, its mecha...
ORGANISM(S): Drosophila melanogaster 
2014-08-14 | E-GEOD-59327 | biostudies-arrayexpress
UnknownPractitioner and researcher perspectives on the utility of ecological momentary assessment in mental health care: A survey study.
Not available
S-EPMC9526140 | biostudies-literature
TranscriptomicsNovel culture conditions facilitating the induction of naïve pluripotency in human embryonic stem cells
We report a novel culture condition inducing naive pluripotency in hESCs in a rapid, robust and reproducible way. These naive hESCs were similar to mESCs exhibiting domed colony morphology, increased single survival, reduced doubling time, upregulation of naive pluripotency-specific genes, unbiased ...
ORGANISM(S): Homo sapiens 
2015-06-29 | E-GEOD-57318 | biostudies-arrayexpress
TranscriptomicsThe Extracellular RNA Quality Control (exRNAQC) study: Small RNA sequencing of interaction study (exRNAQC017)
Study to detect possible interactions between blood collection tubes and RNA purification methods on extracellular RNA (exRNA) sequencing. Different combinations of blood collection tubes (3 in total), time intervals between blood draw and downstream processing (immediate (T0), after 4 hours (T4), a...
ORGANISM(S): Homo sapiens 
2022-12-25 | E-MTAB-12542 | biostudies-arrayexpress
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