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MetabolomicsMolecular investigation of Tuscan sweet cherries sampled over three years: gene expression analysis coupled to metabolomics and proteomics

Sweet cherry (Prunus avium L.) is a stone fruit widely consumed and appreciated for its organoleptic properties, as well as its nutraceutical potential. We here investigated the characteristics of six non-commercial Tuscan varieties of sweet cherry maintained at the Regional Germplasm Ba...

2021-10-29 | MTBLS1803 | MetaboLights
MetabolomicsMetabolomic and gene expression approaches reveal the developmental and environmental regulation of the secondary metabolism of yacón (Smallanthus sonchifolius, Asteraceae)
Acting as chemical defense or signaling compounds, secondary metabolites (SMs) play an essential role in the evolutionary success of many angiosperm plant families. However, the adaptive advantages that SMs confer, and the influence of environmental and developmental factors on SMs expression, remai...
2020-03-24 | MTBLS840 | MetaboLights
TranscriptomicsHepatic transcriptome of mice with a deletion of the miR-379/miR-410 cluster at P1
In placental mammals, adaptation to extra-uterine life requires complex metabolic adjustments linked to the abrupt transition from the transplacental transfer of glucose toward the use of fat originating from the motherM-bM-^@M-^Ys milk as a major energy source. The study of a novel knock-out mouse ...
ORGANISM(S): Mus musculus 
2014-08-22 | E-GEOD-57112 | biostudies-arrayexpress
MetabolomicsDefective cytokinin signaling reprograms lipid and flavonoid gene-to-metabolite networks to mitigate high salinity in Arabidopsis

Cytokinin (CK) in plants regulates both developmental processes and adaptation to environmental stress. Arabidopsis histidine phosphotransfer ahp2,3,5 and type-B response regulator arr1,10,12 triple mutants are almost completely defective in CK signaling, and the ahp2,3,5

2021-11-25 | MTBLS2532 | MetaboLights
TranscriptomicsHepatic transcriptome of mice with a deletion of the miR-379/miR-410 cluster at E19.5 and P0
In placental mammals, adaptation to extra-uterine life requires complex metabolic adjustments linked to the abrupt transition from the transplacental transfer of glucose toward the use of fat originating from the motherM-bM-^@M-^Ys milk as a major energy source. The study of a novel knock-out mouse ...
ORGANISM(S): Mus musculus 
2014-08-22 | E-GEOD-47156 | biostudies-arrayexpress
TranscriptomicsHepatic transcriptome of mice with a deletion of the miR-379/miR-410 cluster obtained 4h following a caesarean at embryonic day E19.5
In placental mammals, adaptation to extra-uterine life requires complex metabolic adjustments linked to the abrupt transition from the transplacental transfer of glucose toward the use of fat originating from the motherM-bM-^@M-^Ys milk as a major energy source. The study of a novel knock-out mouse ...
ORGANISM(S): Mus musculus 
2014-08-22 | E-GEOD-47155 | biostudies-arrayexpress
MetabolomicsEvolutionary novelty of Apolipoprotein D facilitates metabolic plasticity in lepidopteran wings

Understanding metabolic plasticity of animal evolution is a fundamental challenge in evolutionary biology. Owing to the diversification of insect wing morphology and dynamic energy requirements, the molecular adaptation mechanisms underlying the metabolic pathways in wing evolution remain largely...

2026-03-29 | MTBLS11285 | MetaboLights
TranscriptomicsAn Integrated Metabolic Atlas of Clear Cell Renal Cell Carcinoma
Changes in cellular metabolism contribute to the development and progression of tumors, and can render tumors vulnerable to interventions. However, studies of human cancer metabolism remain limited due to technical challenges of detecting and quantifying small molecules, the highly interconnected na...
ORGANISM(S): Homo sapiens 
2016-03-08 | E-GEOD-74734 | biostudies-arrayexpress
MetabolomicsEvolutionary novelty of Apolipoprotein D facilitates metabolic plasticity in lepidopteran wing

Understanding metabolic plasticity of animal evolution is a fundamental challenge in evolutionary biology. Owing to the diversification of insect wing morphology and dynamic energy requirements, the molecular adaptation mechanisms underlying the metabolic pathways in wing evolution remain largely...

2026-03-29 | MTBLS4308 | MetaboLights
MetabolomicsGut microbiome dysbiosis drives metabolic dysfunction in Familial dysautonomia
Familial dysautonomia (FD) is a rare genetic neurologic disorder caused by impaired neuronal development and progressive degeneration of both the peripheral and central nervous systems. FD is monogenic, with >99.4% of patients sharing an identical point mutation in the elongator acetyltransferase co...
2022-12-06 | MTBLS5138 | MetaboLights
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