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MetabolomicsMetabolic Profiling of Escherichia coli-Based Cell-Free Expression Systems for Process Optimization
Biotechnology has transformed the production of various chemicals and pharmaceuticals due to its efficient and selective processes, but it is inherently limited by its use of live cells as 'biocatalysts.' Cell-free expression (CFE) systems, which use a protein lysate isolated from whole cells, have ...
2020-06-02 | MTBLS1079 | MetaboLights
MetabolomicsOn-line untargeted metabolomics monitoring of an Escherichia coli succinate fermentation process
The real-time monitoring of metabolites (RTMet) is instrumental for the industrial production of biobased fermentation products. This study shows the first application of untargeted on-line metabolomics for the monitoring of undiluted fermentation broth samples taken automatically from a 5 L bioreac...
2023-04-26 | MTBLS5197 | MetaboLights
MetabolomicsPredicting dying: a study of the metabolic changes and the dying process in patients with lung cancer
Not available
ORGANISM(S): Homo sapiens 
ST002082 | MetabolomicsWorkbench
MetabolomicsThe microbiome is associated with obesity-related metabolome signature in the process of aging

The roles of specific microbial metabolites in aging remains understudied. Here we examine the microbiome’s contribution to the metabolic profile in aged mice. Fecal samples were collected from 8-week-old (young) and 18-month-old (aged) female Swiss-Webster mice raised conventionally (Conv) ...

2025-07-10 | MTBLS10085 | MetaboLights
MetabolomicsMetabolomic analysis reveals a differential adaptation process of the larval stages of Anisakis simplex to the host environment

Anisakis simplex are parasitic nematodes that cause anisakiasis. The possibility of infection with this parasite is through consumption of raw or undercooked fish products. A. simplex infections are often misdiagnosed, especially in subclinical cases that do not present with typ...

2023-07-08 | MTBLS6458 | MetaboLights
MetabolomicsNi-MOFs as a Simple and Effective Nanomedicine for ROS-Mediated Antibacterial Wound Healing via a Themoelectrocatalytic Process

Thermoelectrocatalytic nickel-based metal-organic frameworks (Ni-MOFs) autonomously generate reactive oxygen species (ROS) via human body-ambient temperature differences. They exhibit potent antibacterial activity against wound-infecting pathogens, and effectively promote infected skin wound heal...

2026-03-13 | MTBLS14045 | MetaboLights
MetabolomicsSex-specific metabolic shifts in plasma of COVID-19 patients after cure
Metabolic profiling in COVID-19 patients has been associated with disease severity, but there is no report on sex-specific metabolic changes in discharged survivors. Herein we used an integrated approach of LC-MS-and GC-MS-based untargeted metabolomics to analyze plasma metabolic characteristics in ...
2022-01-10 | MTBLS2224 | MetaboLights
ProteomicsAcetylation profiles in the metabolic process of glioma-associated seizures
We used label-free based mass spectrometry-based quantitative proteomics to quantify dynamic changes of protein acetylation between gliomas with seizure (CA1 group) and gliomas without seizure (CA2 group).We further classified acetylated proteins into groups according to cell component, molecular fu...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027864 | Pride
Metabolic process Glioma-associated seizures Lysine acetylation 
MetabolomicsThe pyruvate kinase, a metabolic sensor powering glycolysis, drives the metabolic control of DNA replication

BACKGROUND: In all living organisms, DNA replication is exquisitely regulated in a wide range of growth conditions to achieve timely and accurate genome duplication prior to cell division. Failures in this regulation cause DNA damage with potentially disastrous consequences ...

2022-04-19 | MTBLS4415 | MetaboLights
MetabolomicsMetabolic Reprogramming and Reliance in Human Skin Wound Healing
Impaired skin wound healing is a significant global health issue, especially among the elderly. Wound healing is a well-orchestrated process involving the sequential phases of inflammation, proliferation, and tissue remodeling. Although wound healing is a highly dynamic and energy-requiring process,...
2024-07-02 | MTBLS3315 | MetaboLights
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