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MetabolomicsChlorophyll biosynthesis under the control of arginine metabolism.

In natural environments, photosynthetic organisms adjust their metabolism to cope with the fluctuating availability of combined nitrogen sources, a growth-limiting factor. For acclimation, the dynamic degradation/synthesis of tetrapyrrolic pigments, as well as of the amino acid arginine, is ...

2024-03-12 | MTBLS8336 | MetaboLights
MetabolomicsEmerging mechanisms and promising approaches in pancreatic cancer metabolism.

Pancreatic cancer is an aggressive cancer with a poor prognosis. Metabolic abnormalities are one of the hallmarks of pancreatic cancer, and pancreatic cancer cells can adapt to biosynthesis, energy intake and redox needs through metabolic reprogramming to tolerate nutrient deficiency and hypoxic ...

2025-03-26 | MTBLS12204 | MetaboLights
MetabolomicsNQO1 protects obese mice through improvements in glucose and lipid metabolism.
Chronic nutrient excess leads to metabolic disorders and insulin resistance. Activation of stress-responsive pathways via Nrf2 activation contributes to energy metabolism regulation. Here, inducible activation of Nrf2 in mice and transgenesis of the Nrf2 target, NQO1, conferred protection from diet-...
2024-05-23 | MTBLS2085 | MetaboLights
MetabolomicsSCUBE3 enhances post-myocardial infarction angiogenesis by promoting endothelial fatty acid metabolism.

BACKGROUND: Myocardial infarction (MI), one of the leading causes of mortality worldwide, remains a clinical challenge due to limitations in current therapeutic strategies. The cardiac vascular network, as the fundamental architecture sustaining myocardial function, delivers oxygen and nutrients ...

2025-09-18 | MTBLS13004 | MetaboLights
MetabolomicsAMPK activation induces RALDH+ tolerogenic dendritic cells by rewiring glucose and lipid metabolism.
Dendritic cell (DC) activation and function are underpinned by profound changes in cellular metabolism. Several studies indicate that the ability of DCs to promote tolerance is dependent on catabolic metabolism. Yet the contribution of AMP-activated kinase (AMPK), a central energy sensor promoting c...
2024-08-16 | MTBLS10647 | MetaboLights
MetabolomicsA gut microbe-focused metabolomics pipeline enables mechanistic interrogation of microbiome metabolism.
Not available
ORGANISM(S): Mus musculus 
ST001683 | MetabolomicsWorkbench
MetabolomicsMurine vitamin A deficiency results in a hypermetabolic state and alterations in bacterial community structure and metabolism.(Urine)
Not available
ORGANISM(S): Mus musculus 
ST000907 | MetabolomicsWorkbench
MetabolomicsMurine vitamin A deficiency results in a hypermetabolic state and alterations in bacterial community structure and metabolism. (Serum)
Not available
ORGANISM(S): Mus musculus 
ST000906 | MetabolomicsWorkbench
MetabolomicsMurine vitamin A deficiency results in a hypermetabolic state and alterations in bacterial community structure and metabolism. (Liver)
Not available
ORGANISM(S): Mus musculus 
ST000905 | MetabolomicsWorkbench
ProteomicsTargeted proteome analysis of the central carbon metabolism related enzymes in S. cerevisiae mutant strains
Expression profiles of 110 the central metabolism-related enzymes were obtained by the selected reaction monitoring (SRM) assay methods using LC-MS/MS from the wild type (BY4742), a GCR2 gene deletion strain, and 29 single-gene deletion strains lacking enzyme genes responsible for central carbon met...
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast) 
2017-03-22 | PXD004714 | JPOST Repository
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