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We found that RANKL, expressed by cancer cells or derived from exogenous sources, consistently induced human prostate, breast, kidney, lung and liver cancer cells to colonize or metastasize to bone in an animal model of cancer bone metastasis. RANK-mediated signaling established a premetastatic nich...
ORGANISM(S): Homo sapiens 
Cholangiocarcinoma (CCA) is a type of liver cancer with an aggressive phenotype and dismal outcome in patients. Current treatment options are limited, with surgical resection or transplantation the only possibility with curative intent. This becomes unavailable if CCA metastasizes to distant organs,...
ORGANISM(S): Homo sapiens (Human) 
2023-01-11 | PXD038191 | Pride
SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization
Menin inhibition impairs metastatic colonization of Ewing sarcoma
[original title] Metastatic Canine Mammary Carcinomas can be Identified by a Gene Expression Profile that partly Overlaps with Human Breast Cancer Profiles. Introduction: Similar to human breast cancer mammary tumors of the female dog are commonly associated with a fatal outcome due to the develop...
ORGANISM(S): Canis lupus familiaris 
ACSL4 and polyunsaturated lipids support metastatic extravasation and colonization
Tissue-derived extracellular matrix hydrogels instruct epigenetic adaptation in metastatic colonization
The experiment was design to address the intrinsic differences between metastatic cancer stem cells in the primary tumour and during metastatic colonization in the mouse mammary gland tumour model MMTV-pyMT. Total RNA was prepared from the indicated cancer cells freshly isolated, stained and FACS ...
ORGANISM(S): Mus musculus 
Autophagic turnover of NBR1 restricts metastatic colonization during mammary tumor progression
Metastatic medulloblastoma remodels the local leptomeningeal microenvironment to promote further metastatic colonization and growth
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