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TranscriptomicsAndrogen receptor-coregulators hormone responsiveness LNCaP / GSF
The text description is: LNCaP are androgen receptor expressing prostate carcinoma cells. Genital skin fibroblasts also express the androgen receptor. Cells were either proliferating or they were G0-arrested. Treatment of cells was performed with either the androgen DHT (dihydrotestosterone), the an...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-4454 | biostudies-arrayexpress
TranscriptomicsGene expression of LNCaP cells grown in polyethlene glycol-based hydrogels alone (monocultures) and grown with human osteoblasts as tissue engineered bone (co-culture) with the presence of synthetic androgen, R1881
Analysis of LNCaP cell molecular differences in monocultures and in co-cultures in the presence of R1881. Human osteoblast molecular signatures were also identified from the tissue engineered bone monocultures. LNCaP cells molecular profile was altered by co-culturing with human osteoblasts compared...
ORGANISM(S): Homo sapiens 
2014-05-13 | E-GEOD-44143 | biostudies-arrayexpress
TranscriptomicsAndrogen receptor-coregulators hormone responsiveness LNCaP / GSF
The text description is: LNCaP are androgen receptor expressing prostate carcinoma cells. Genital skin fibroblasts also express the androgen receptor. Cells were either proliferating or they were G0-arrested. Treatment of cells was performed with either the androgen DHT (dihydrotestosterone), the an...
ORGANISM(S): Homo sapiens 
2006-10-12 | GSE4454 | GEO
TranscriptomicsTranscription profiling of human androgen receptor expressing prostate carcinoma cell line LNCaP and normal human foreskin fibroblasts expressing the androgen receptor treated with dihydrotestosterone (DHT), ethanol, or untreated vs. a common reference, see E-SMDB-3636
The text description is: LNCaP are androgen receptor expressing prostate carcinoma cells. Genital skin fibroblasts also express the androgen receptor. Cells were either proliferating or they were G0-arrested. Treatment of cells was performed with either the androgen DHT (dihydrotestosterone), the an...
ORGANISM(S): Homo sapiens 
2006-11-06 | E-SMDB-3637 | biostudies-arrayexpress
TranscriptomicsRNA-seq in the U2OS-AR cell line to identify genes regulated by the androgen receptor
To identify the genes regulated by the androgen receptor (AR), we performed RNA-seq in the U2OS-AR cell line (derived from U2OS ATTC:HTB-96, stably transfected with an expression construct for human AR), upon androgen (R1881) or vehicle (DMSO) treatment for 24 hours.
ORGANISM(S): Homo sapiens 
2021-03-09 | E-MTAB-9622 | biostudies-arrayexpress
TranscriptomicsATAC-seq in the U2OS-AR cell line comparing cells treated for 4 hours with 5 nM R1881 to vehicle (DMSO) control-treated cells
We performed ATAC-seq in the U2OS-AR cell line (derived from U2OS ATTC:HTB-96, stably transfected with an expression construct for human AR), upon androgen (R1881) or vehicle (DMSO) treatment for 4 hours.
ORGANISM(S): Homo sapiens 
2021-03-09 | E-MTAB-9606 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human prostate cancer cells after I?-TrCP inhibition and androgen ablation in prostate cancer cells
We examined gene expression of LAPC4 cells after knocking down β-TrCP, androgen ablation, or the combined treatments compared to non treated cells. Experiment Overall Design: Using lentiviral vectors, we stably infected LAPC4 cells with specific shRNA targeted for both β-TrCP isoforms (i.e. 1 and ...
ORGANISM(S): Homo sapiens 
2009-11-28 | E-GEOD-19141 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of human LNCaP cells treated with synthetic androgen R1881 or ethanol (vehicle) using androgen receptor antibody
LNCaP cells were grown in charcoal stripped media for 48hrs and then treated for 1hr with the synthetic androgen R1881 or ethanol (vehicle). Cell extracts from both treatment conditions were then subjected to chromatin-immunoprecipitation using an anti-androgen receptor antibody, before labeling and...
ORGANISM(S): Homo sapiens 
2007-08-17 | E-TABM-233 | biostudies-arrayexpress
TranscriptomicsGene expression of LNCaP cells grown in 2D cultures and polyethlene glycol-based hydrogels with the presence of synthetic androgen, R1881
Analysis of LNCaP cell molecular differences and their response to R1881 in 2D and 3D cultures. Androgen regulated genes were differentially expressed between 2D and 3D cultures. These results provide insights into factors that influence the expression of androgen regulated genes In this study, LNCa...
ORGANISM(S): Homo sapiens 
2013-02-04 | E-GEOD-33610 | biostudies-arrayexpress
TranscriptomicsLong-term androgen withdrawal and treatment (R1881) of LNCaP-FGC prostate cancer cells
LNCaP cells were cultures in steroid depleted medium for 5 days before treatment with synthetic androgen (R1881, 10nM) for 16h. Transcriptomics analysis was performed to compare gene expression changes induced by androgen withdrawal or androgen treatment. Genome-wide transcriptomic analysis of LNCaP...
ORGANISM(S): Homo sapiens 
2013-10-22 | E-GEOD-51460 | biostudies-arrayexpress
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