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ProteomicsThe proteins detection in the Early Stage of Myocardial Infarction
Eight-week-old mice were divided into six groups: sham group, 10min after MI, 1h after MI, 6h after MI, 24h after MI and 72h after MI. Myocardial infarction was performed by ligating the proximal left anterior descending coronary artery. Then the infarction myocardial tissue was taken for DIA protei...
ORGANISM(S): Mus Musculus 
2020-07-05 | PXD020193 |
ProteomicsA Stress-Adaptive Lipid Kinase Axis Defines Metabolic Vulnerabilities in Neuroendocrine Prostate Cancer
Neuroendocrine prostate cancer (NEPC) persists in a profoundly hypoxic microenvironment, yet the mechanisms enabling tumor adaptation to this metabolically challenging niche remain undefined. Here, we identify the lipid kinase PIKfyve as overexpressed in NEPC, functioning as a central node in a stre...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD076640 | Pride
UnknownDiscovery of the first selective and potent PROTAC degrader for the pseudokinase TRIB2.
Not available
S-EPMC12135709 | biostudies-literature
TranscriptomicsAffymetrix gene arrays of leukemic BM samples from 24 mice including 9 primary
To identify such targets of leukemia-related miRNAs such as miR-196b, we conducted Affymetrix gene arrays of leukemic BM samples from 24 mice including 9 primary (including 3 each of negative control, MLL-AF9, and miR-196b+MLL-AF9) and 15 secondary (including 3 negative control, 6 MLL-AF9, and 6 miR...
ORGANISM(S): Mus musculus 
2012-08-09 | E-GEOD-34185 | biostudies-arrayexpress
TranscriptomicsMiRNA expression profile in murine advanced atherosclerotic plaque compared with early atherosclerotic plaque
Aberrantly expressed miRNAs contribute to developmental abnormalities and diseases such as cancer, diabetes, and cardiovascular disorders, by hybridizing to specific mRNA targets and repressing their translation into proteins. Although miRNA expression signature is characterized in the process of ne...
ORGANISM(S): Mus musculus 
2013-03-27 | E-GEOD-34647 | biostudies-arrayexpress
TranscriptomicsMiRNA expression profile in murine advanced atherosclerotic plaque compared with un-diseased arterial wall
Aberrantly expressed miRNAs contribute to developmental abnormalities and diseases such as cancer, diabetes, and cardiovascular disorders, by hybridizing to specific mRNA targets and repressing their translation into proteins. Although miRNA expression signature is characterized in the process of ne...
ORGANISM(S): Mus musculus 
2013-03-27 | E-GEOD-34644 | biostudies-arrayexpress
TranscriptomicsMiRNA expression profile in murine early atherosclerotic plaque compared with un-diseased arterial tissue
Aberrantly expressed miRNAs contribute to developmental abnormalities and diseases such as cancer, diabetes, and cardiovascular disorders, by hybridizing to specific mRNA targets and repressing their translation into proteins. Although miRNA expression signature is characterized in the process of ne...
ORGANISM(S): Mus musculus 
2013-03-27 | E-GEOD-34645 | biostudies-arrayexpress
TranscriptomicsMiRNA expression profile in murine un-diseased arterial tissue on 3 month high fat diet vs 10 month high fat diet
Aberrantly expressed miRNAs contribute to developmental abnormalities and diseases such as cancer, diabetes, and cardiovascular disorders, by hybridizing to specific mRNA targets and repressing their translation into proteins. Although miRNA expression signature is characterized in the process of ne...
ORGANISM(S): Mus musculus 
2013-03-27 | E-GEOD-34646 | biostudies-arrayexpress
TranscriptomicsIdentification of prognostic gene signatures in AML
Increased expression levels of miR-181 family members have been shown to be associated with favorable outcome in patients with cytogenetically normal acute myeloid leukemia. Here we show that increased expression of miR-181a and miR-181b is also significantly (P < .05; Cox regression) associated wit...
ORGANISM(S): Homo sapiens 
2012-04-03 | E-GEOD-30285 | biostudies-arrayexpress
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