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TranscriptomicsGenome wide analysis of pancreatic gene expression by Interleukin 1M-NM-2 in human epithelial pancreatic Mia Paca-2 cells.
Analysis of the pancreatic gene expression with IL-1M-NM-2 stimulation. Components of the integrin pathway were significantly altered with IL-1M-NM-2 which play critical role in the execution of apoptosis.The results revealed several important cellular pathways and the biological processes of the ge...
ORGANISM(S): Homo sapiens 
2012-06-20 | E-GEOD-26702 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Mia PaCa-2 cancer cells treated with a cell-permeable RAS inhibitor and its negative control
The action mechanism of a cell-permeable RAS inhibitor (Pen-cRaf-v1) and its binding-disrupting mutant (Pen-cRaf-v1-AA) was studied by transcription profiling of Mia PaCa-2 cancer cells treated with the inhibitors at the concentration of 10 microM for 3 hours.
ORGANISM(S): Homo sapiens 
2021-06-01 | E-MTAB-10403 | biostudies-arrayexpress
TranscriptomicsA GNAS mutation found in pancreatic intraductal papillary mucinous neoplasms induces drastic alterations of gene expression profiles with upregulation of mucin genes.
GNAS, a gene encoding G-protein stimulating alpha subunit, is frequently mutated in intraductal papillary mucinous neoplasms (IPMNs), which is an indolent and slow-growing pancreatic neoplasm that secretes abundant mucin. GNAS mutation is not observed in conventional ductal adenocarcinomas of the pa...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-53350 | biostudies-arrayexpress
TranscriptomicsRole of mevalonate pathway intermediates in anticancer effect of statins
Simvastatin has been widely used for treatment of hypercholesterolemia due to its ability to inhibit HMG-CoA reductase, the rate limiting enzyme of de novo cholesterol synthesis via mevalonate pathway. Its inhibitory action causes also depletion of pathway intermediates, farnesyl pyrophosphate (FPP)...
ORGANISM(S): Homo sapiens 
2018-03-31 | E-MTAB-3263 | biostudies-arrayexpress
TranscriptomicsPachymic acid inhibits growth and induces apoptosis of pancreatic cancer in vitro and in vivo by targeting ER stress
Background: Pachymic acid (PA) is a purified triterpene extracted from medicinal fungus Poria cocos. In this paper, we investigated the anticancer effects of PA on human chemotherapy resistant pancreatic cancer cells. Methods: Gemcitabine-resistant pancreatic cancer cells PANC-1 and MIA PaCa-2 were...
ORGANISM(S): Homo sapiens 
2014-12-12 | E-GEOD-64111 | biostudies-arrayexpress
UnknownMitochondrial translocation of APE1 relies on the MIA pathway.
Not available
S-EPMC4477663 | biostudies-literature
ProteomicsProteomics approach unravels early changes in Human Fibro-blasts-Pancreatic Ductal Adenocarcinoma cells crosstalk
Pancreatic ductal adenocarcinoma (PDAC) is a leading causes of cancer mortality worldwide. Non-specific symptoms, lack of biomarkers in the early stages, and drug resistance due to the presence of a dense fibrous stroma all contribute to poor outcome of this disease. The extracellular matrix of PDAC...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD030974 | Pride
Cancer associated fibroblasts  pdac microenvironment  proteomics  ingenuity pathway analysis 
TranscriptomicsNetworking of differentially expressed genes in human MIA PaCa2 pancreatic cancer cells resistant to methotrexate
A summary of the work associated to these microarrays is the following: The need for an integrated view of all data obtained from high-throughput technologies gave rise to network analyses. These are especially useful to rationalize phenomena in terms of how external perturbations propagate through ...
ORGANISM(S): Homo sapiens 
2009-09-08 | E-GEOD-16082 | biostudies-arrayexpress
TranscriptomicsIdentification of target genes of miR-193b
Searching of target genes of miR-193b by transcriptome assay using 44K Whole Human Genome Microarray system (Agilent Technologies, Palo Alto, CA) resulted in finding of several candidate genes. To search of targets genes of miR-193b, we performed transcriptome analysis to compare expression profiles...
ORGANISM(S): Homo sapiens 
2012-03-14 | E-GEOD-25215 | biostudies-arrayexpress
UnknownThe MIA pathway: a key regulator of mitochondrial oxidative protein folding and biogenesis.
Not available
S-EPMC4551283 | biostudies-literature
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