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TranscriptomicsLPS stimulation of human PBMC-derived macrophages
Immunoresponsive gene 1 (IRG1) is one of the highest induced genes in macrophages under pro-inflammatory conditions and its function has been recently described: it codes for immune-responsive gene 1 protein/cis-aconitic acid decarboxylase (IRG1/CAD), an enzyme catalyzing the production of itaconic ...
ORGANISM(S): Homo sapiens 
2016-02-25 | E-GEOD-76561 | biostudies-arrayexpress
TranscriptomicsLPS stimulation of Mouse (RAW 264.7) macrophages
Immunoresponsive gene 1 (IRG1) is one of the highest induced genes in macrophages under pro-inflammatory conditions and its function has been recently described: it codes for immune-responsive gene 1 protein/cis-aconitic acid decarboxylase (IRG1/CAD), an enzyme catalyzing the production of itaconic ...
ORGANISM(S): Mus musculus 
2016-02-25 | E-GEOD-76562 | biostudies-arrayexpress
TranscriptomicsInflammation promotes a conversion of astrocytes into neural progenitor cells via NF-kB activation
Brain inflammation, a common feature in neurodegenerative diseases, is a complex series of events, which can be detrimental and even lead to neuronal death. Nonetheless, several studies suggest that inflammatory signals are also positively influencing neural cell proliferation, survival, migration a...
ORGANISM(S): Mus musculus 
2015-09-16 | E-GEOD-73022 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of macrophages derived from mouse bone marrow cells with or without metformin treatment
In this study, we investigated the effects of metformin on the differentiation of bone marrow-derived macrophages (BMDMs) and their potential role in cancer immunity. BMDMs were generated from bone marrow cells extracted from C57BL/6N mice and differentiated in the presence or absence of metformin. ...
ORGANISM(S): Mus musculus 
2025-06-13 | E-MTAB-14199 | biostudies-arrayexpress
UnknownSingle-cell transcriptomics reveals distinct inflammation-induced microglia signatures
Not available
S-SCDT-EMBOR-2018-46171-T | biostudies-other
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