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MetabolomicsCascading effects of root microbial symbiosis on the development and metabolome of the insect herbivore Manduca sexta L

Root mutualistic microbes can modulate the production of plant secondary metabolites affecting plant–herbivore interactions. Still, the main mechanisms underlying the impact of root mutualists on herbivore performance remain ambiguous. In particular, little is known about how changes in the plant...

2023-09-12 | MTBLS2700 | MetaboLights
MetabolomicsPlasmid-encoded toxin defence mediates mutualistic microbial interactions

Gut environments harbour dense microbial ecosystems in which plasmids are widely distributed. Plasmids facilitate the exchange of genetic material among microorganisms while enabling the transfer of a diverse array of accessory functions. However, their precise impact on microbial community compo...

2023-08-10 | MTBLS7248 | MetaboLights
MetabolomicsStage-specific roles of microbial dysbiosis and metabolic disorders in rheumatoid arthritis

OBJECTIVE: Rheumatoid arthritis (RA) is a progressive disease including four stages, where gut microbiome is associated with pathogenesis. We aimed to investigate stage-specific roles of microbial dysbiosis and metabolic disorders in RA.

METHODS: We investi...

2023-01-31 | MTBLS5297 | MetaboLights
MetabolomicsSmall intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders
Small intestinal bacterial overgrowth (SIBO) has been implicated in symptoms associated with functional gastrointestinal disorders (FGIDs), though mechanisms remain poorly defined and treatment involves non-specific antibiotics. Here we show that SIBO based on duodenal aspirate culture reflects an o...
2019-04-30 | MTBLS876 | MetaboLights
MetabolomicsButyrate deficiency due to microbial dysbiosis promotes anxiety

for this association remains incompletely understood. Diabetes-associated genes have been implicated in the control of central nervous system (CNS) disorders. In the current study, we observed a significant downregulation of secretagogin (SCGN) across multiple organs in diabetic mouse models. Con...

2026-03-01 | MTBLS13477 | MetaboLights
MetabolomicsMicrobial metabolites calibrate innate immunity upon systemic viral infection

Gut microbiome dysbiosis is often associated with immune-mediated diseases. Here, we used germ-free (GF) mice, the synthetic minimal consortium OMM12, and specific pathogen-free (SPF) mice to dissect the causal influence of the microbiome on anti-viral immunity. The lack of microbial diversity af...

2026-08-01 | MTBLS7382 | MetaboLights
GenomicsDiabetes induced microbiome dysbiosis is associated with therapy resistance in Pancreatic Ductal Adenocarcinoma (PDAC)
Pancreatic cancer is the 3rd most prevalent cause of cancer related deaths in United states alone, with over 55000 patients being diagnosed in 2019 alone and nearly as many succumbing to it. Late detection, lack of effective therapy and poor understanding of pancreatic cancer systemically contribute...
ORGANISM(S): mouse gut metagenome 
2020-11-30 | E-MTAB-8739 | biostudies-arrayexpress
TranscriptomicsRapidly induced fucosylation of intestinal epithelium sustains host-commensal symbiosis during sickness.
Systemic infection induces conserved physiological responses that include both resistance and ‘tolerance of infection’ mechanisms. Among these responses, temporary anorexia associated with an infection is often beneficial. It poses, however, a problem for the trillions of microbes residing in the ga...
ORGANISM(S): mouse gut metagenome 
2014-10-24 | E-GEOD-60874 | biostudies-arrayexpress
MetabolomicsPenicillium-Mediated Toxicity and Microbial Dysbiosis Are Associated with Fruiting Body Abortion in Artificially Cultivated Ophiocordyceps sinensis

The Chinese caterpillar fungus, Ophiocordyceps sinensis, is a valuable medicinal entomopathogenic fungus, but artificial cultivation is hindered by fruiting body abortion, severely impacting yield and quality. The interactions between the fungus, its host insects, and soil are critical for its de...

2026-06-24 | MTBLS14844 | MetaboLights
MetabolomicsIntegrated Gut Microbiome and Metabolomics Analysis Reveals Microbial-Metabolic Cross-talk in Allergic Rhinitis

Background: Emerging evidence indicates a link between gut dysbiosis and allergic rhinitis (AR) pathogenesis. Nevertheless, the mechanistic role of gut microbiota in AR progression requires further characterization. To address this, we employed an integrated multi-omics strategy to delineat...

2025-09-22 | MTBLS13021 | MetaboLights
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