Sort   by:  
 Page size 
MetabolomicsEssential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the developing brain

Omega-3 fatty acids (n-3 polyunsaturated fatty acids; n-3 PUFAs) are essential for the functional maturation of the brain. Westernization of dietary habits in both developed and developing countries is accompanied by a progressive reduction in dietary intake of n-3 PUFAs. Low maternal intake of n...

2020-11-03 | MTBLS1952 | MetaboLights
TranscriptomicsTranscription profiling of neonatal rat microglia after IFN-gamma activation
IFN-gamma is a classical microglial stimulant. We used microarrays to investigate the microglial gene regulatory network activated by interferon-gamma. Experiment Overall Design: Primary rat microglia cultures were established and maintained for 15 days. For activation studies, fresh media containi...
ORGANISM(S): Rattus norvegicus 
2008-06-14 | E-GEOD-6353 | biostudies-arrayexpress
TranscriptomicsRepeated systemic challenge with lipopolysaccharides induces dopaminergic neurodegeneration in the brain by activation of the complement-phagosome pathway
Systemic inflammatory reactions mediated by chronic infections activate microglia in the central nervous system (CNS) and have been postulated to exacerbate neurodegenerative diseases. We now demonstrate in vivo that repeated systemic challenge of mice with bacterial lipopolysaccharides (LPS) mainta...
ORGANISM(S): Mus musculus 
2014-07-11 | E-MTAB-1770 | biostudies-arrayexpress
TranscriptomicsTREM2 regulates microglial cell activation in response to demyelination in vivo
Microglia are phagocytic cells that survey the brain and perform neuroprotective functions in response to tissue damage, but their activating receptors are largely unknown. Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial immunoreceptor whose loss-of-function mutations in hum...
ORGANISM(S): Mus musculus 
2015-07-06 | E-GEOD-70475 | biostudies-arrayexpress
TranscriptomicsMicroglial response to A? and prostaglandin-E2 EP4 receptor activation
A persistent and non-resolving inflammatory response to accumulating A? peptide species is a cardinal feature in the development of Alzheimer's disease (AD). In response to accumulating A? peptide species, microglia, the innate immune cells of the brain, generate a toxic inflammatory response that a...
ORGANISM(S): Mus musculus 
2014-04-25 | E-GEOD-55627 | biostudies-arrayexpress
TranscriptomicsMicroglia in ischemic brain injury
Microglia are resident CNS immune cells that are active sensors in healthy brain and versatile effectors under pathological conditions. Cerebral ischemia induces a robust neuroinflammatory response that includes marked changes in the gene expression and phenotypic profile of a variety of endogenous ...
ORGANISM(S): Mus musculus 
2010-10-05 | E-GEOD-18602 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series of the response of human microglial cells to interferon gamma
Microglial cells are resident macrophages in the central nervous system (CNS) and play a pivotal role in the innate and adaptive immune responses against microbial infections. The immune functions of microglia are regulated by a milieu of cytokines including interferon (IFN)-gamma. We here performed...
ORGANISM(S): Homo sapiens 
2007-08-03 | E-GEOD-1432 | biostudies-arrayexpress
OtherNovel molecular insights into classical and alternative activation states of microglia as revealed by SILAC-based proteomics.
Data from ProteomeXchange, 888 Proteomic analysis of microglial activation states, 1676 Microglial activation characterization. Experiment: BV2_IL102, file: folder summary. Published as part of Mol Cell Proteomics. 2015 Sep 30 . From the Abstract: {{i}} Microglia, the resident immune cells of the b...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM11210041929 | GPMDB
OtherNovel molecular insights into classical and alternative activation states of microglia as revealed by SILAC-based proteomics.
Data from ProteomeXchange, 888 Proteomic analysis of microglial activation states, 1676 Microglial activation characterization. Experiment: BV2_LPS_1, file: folder summary. Published as part of Mol Cell Proteomics. 2015 Sep 30 . From the Abstract: {{i}} Microglia, the resident immune cells of the b...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32320019104 | GPMDB
TranscriptomicsTranscription profiles of BV2 microglial cell lines- unstimulated or stimulated with LPS or transfected with constitutively active Stat1 and Stat3.
Transcription profiles of BV2 microglial cell lines: unstimulated, stimulated with LPS or transfected with constitutively active Stat1 and Stat3.
ORGANISM(S): Mus musculus 
2014-06-19 | E-MEXP-3659 | biostudies-arrayexpress
Sort   by:  
 Page size