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MetabolomicsTFAM-Associated Mitochondrial Dynamics and Metabolic Reprogramming Regulate Microglial Polarization: Temporal and Causal Perspectives

The polarization state of microglia exerts an influence on neuroinflammation and neural tissue repair after injury. Modulating microglial polarization is emerging as a potential therapeutic strategy for various types of neural injuries and neurodegenerative diseases. However, the causal relations...

2025-12-23 | MTBLS13564 | MetaboLights
MetabolomicsMicrobiota network modules-derived tryptophan metabolites improve cognition via microglial AhR/Sirpα signaling
Gut microbiota dysbiosis has emerged as one of the hallmarks of aging, highlighting the need to identify microbial network modules as new biomarkers rooted in microbiota interactions and develop targeted nutritional interventions. The current research, integrating data from Alzheimer's disease (AD) ...
2026-08-07 | MTBLS15265 | MetaboLights
MetabolomicsMicrobiota network modules-derived tryptophan metabolites improve cognition via microglial AhR/Sirpα signaling

Gut microbiota dysbiosis has emerged as one of the hallmarks of aging, highlighting the need to identify microbial network modules as new biomarkers rooted in microbiota interactions and develop targeted nutritional interventions. The current research, integrating data from Alzheimer's disease (A...

2026-08-08 | MTBLS12506 | MetaboLights
MetabolomicsMicrobiota network modules-derived tryptophan metabolites improve cognition via microglial AhR/Sirpα signaling

Gut microbiota dysbiosis has emerged as one of the hallmarks of aging, highlighting the need to identify microbial network modules as new biomarkers rooted in microbiota interactions and develop targeted nutritional interventions. The current research, integrating data from Alzheimer's disease (A...

2026-08-08 | MTBLS12508 | MetaboLights
TranscriptomicsTranscription profiling of mouse primary microglial cultures with and without neurovirulent (FrCasE) and non-neurovirulent (Fr57E) virus infection
We undertook a survey of gene expression changes in primary microglial cultures with and without neurovirulent (FrCasE) and non-neurovirulent (Fr57E) virus infection to identify physiological changes that could be relevant to the induction of spongiform neurodegeneration. These gene expression analy...
ORGANISM(S): Mus musculus 
2005-05-11 | E-MEXP-459 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series of the response of human microglial cells to interferon gamma
Microglial cells are resident macrophages in the central nervous system (CNS) and play a pivotal role in the innate and adaptive immune responses against microbial infections. The immune functions of microglia are regulated by a milieu of cytokines including interferon (IFN)-gamma. We here performed...
ORGANISM(S): Homo sapiens 
2007-08-03 | E-GEOD-1432 | biostudies-arrayexpress
TranscriptomicsMicroglia in ischemic brain injury
Microglia are resident CNS immune cells that are active sensors in healthy brain and versatile effectors under pathological conditions. Cerebral ischemia induces a robust neuroinflammatory response that includes marked changes in the gene expression and phenotypic profile of a variety of endogenous ...
ORGANISM(S): Mus musculus 
2010-10-05 | E-GEOD-18602 | biostudies-arrayexpress
TranscriptomicsRNA-seq of mouse brain tissue repopulating microglia in response to traumatic brain injury
We assessed the roles of repopulating microglia in brain repair using mouse models. In this project, we show that removal of microglia from the mouse brain has little impact on the outcome of TBI but inducing the turnover of these cells through either pharmacologic or genetic approaches can yield a ...
ORGANISM(S): Mus musculus 
2020-02-15 | E-MTAB-8765 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of neonatal rat microglia after IFN-gamma activation
IFN-gamma is a classical microglial stimulant. We used microarrays to investigate the microglial gene regulatory network activated by interferon-gamma. Experiment Overall Design: Primary rat microglia cultures were established and maintained for 15 days. For activation studies, fresh media containi...
ORGANISM(S): Rattus norvegicus 
2008-06-14 | E-GEOD-6353 | biostudies-arrayexpress
ProteomicsDocosahexaenoic acid attenuates metabolic dysfunctions induced by lipopolysaccharide in BV-2 microglial cells
Microglial cell activation has been linked to many neurodegenerative diseases. Upon stimulation by lipopolysaccharide (LPS), a number of proteins involved in inflammatory and oxidative pathways are activated. Production of nitric oxide has been regarded as a signature marker of inflammatory response...
ORGANISM(S): Mus musculus (Mouse) 
2020-04-20 | PXD013086 | Pride
Lipopolysaccharide Tims Docosahexaenoic acid Label-free quantification Microglia Time-of-flight. Ion mobility 
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