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GenomicsAnalysis of Control and Liver-specific Mier1 KO Liver Transcriptomes after 70% Partial Hepatectomy
Analysis of Control and Liver-specific Mier1 KO Liver Transcriptomes after 70% Partial Hepatectomy
PRJNA778762 | ENA
UnknownA potential histone-chaperone activity for the MIER1 histone deacetylase complex.
Not available
S-EPMC10325919 | biostudies-literature
UnknownThe transcriptional cofactor MIER1-beta negatively regulates histone acetyltransferase activity of the CREB-binding protein.
Not available
S-EPMC2546418 | biostudies-literature
TranscriptomicsAnalysis of Control and Liver-specific Mier1 KO Liver Transcriptomes after 70% Partial Hepatectomy
To explore how Mier1 affiects liver regeneration, we specifically knocked out Mier1 in mouse liver through adeno-associated virus (AAV). The mice we used were knocked in a Cre-induced Cas9 expression cassette. Through tail vein injection, we delivered the AAV expressing Cre-recombinase under TBG pro...
ORGANISM(S): Mus musculus 
2022-12-30 | GSE188421 | GEO
ProteomicsAn unexpected histone-binding activity for the MIER1 histone deacetylase complex suggests a potential chaperone function.
Histone deacetylases 1 and 2 (HDAC1/2) serve as the catalytic subunit of six distinct families of nuclear complexes. These complexes repress gene transcription through removing acetyl groups from lysine residues in histone tails. In addition to the deacetylase subunit, these complexes typically cont...
ORGANISM(S): Homo sapiens (Human) 
2023-04-14 | PXD040685 | Pride
Methylation Deacetylase Histone 
ProteomicsAn unexpected histone-binding activity for the MIER1 histone deacetylase complex suggests a potential chaperone function.
Histone deacetylases 1 and 2 (HDAC1/2) serve as the catalytic subunit of six distinct families of nuclear complexes. These complexes repress gene transcription through removing acetyl groups from lysine residues in histone tails. In addition to the deacetylase subunit, these complexes typically cont...
ORGANISM(S): Homo sapiens (Human) 
2024-11-27 | PXD036303 | Pride
Methylation Deacetylase Histone 
GenomicsMIER1-FLAG ChIP-seq Analysis in Liver at 0 h and 24 h after 70% Partial Hepatectomy
MIER1-FLAG ChIP-seq Analysis in Liver at 0 h and 24 h after 70% Partial Hepatectomy
PRJNA780074 | ENA
UnknownAcute liver steatosis translationally controls the epigenetic regulator MIER1 to promote liver regeneration in a study with male mice.
Not available
S-EPMC10024732 | biostudies-literature
GenomicsATAC-seq Analysis in Control and Mier1 KO Mice Liver at 0 h and 24 h after 70% Partial Hepatectomy
To explore how Mier1 affects liver regeneration, we specifically knocked out Mier1 in mouse liver through adeno-associated virus (AAV). The mice we used were knocked in a Cre-induced Cas9 expression cassette. Through tail vein injection, we delivered the AAV expressing Cre-recombinase under TBG prom...
ORGANISM(S): Mus musculus 
2022-12-31 | GSE212626 | GEO
GenomicsMIER1-FLAG ChIP-seq Analysis in Liver at 0 h and 24 h after 70% Partial Hepatectomy
To explore how Mier1 influence liver regeneration, we performed chromatin immunoprecipitation followed by sequencing in liver tissues at 0 h and 24 h after 70% partial hepatectomy (PHx). Due to a lack of available MIER1 antibody for ChIP-seq analysis, exogenous liver expression of MIER1-FLAG under T...
ORGANISM(S): Mus musculus 
2022-12-30 | GSE188747 | GEO
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