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MetabolomicsProlonged fasting times reap greater geroprotective effects when combined with caloric restriction in adult female mice
Emerging new evidence highlights the importance of prolonged daily fasting periods for the health and survival benefits of calorie restriction (CR) and time-restricted feeding (TRF) in male mice; however, little is known about the impact of these feeding regimens in females. We placed 14-month-old f...
2024-05-14 | MTBLS790 | MetaboLights
TranscriptomicsBisphosphonate related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in MM
We have explored the potential role of genetics in the development of osteonecrosis of the jaw (ONJ) in multiple myeloma (MM) patients under bisphosphonate therapy. A genome wide association study was performed using 500.568 single nucleotide polymorphisms (SNPs) in two series of homogeneously treat...
ORGANISM(S): Homo sapiens 
2008-09-25 | E-GEOD-11948 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of bone marrow samples from human acute myeloid leukemia patients
Gene expression profile of acute myeloid leukemia. Bone marrow (BM) samples from 43 adult patients with newly de novo diagnosed AML.All samples contained more than 80% blast cells. Total RNA was extracted using Trizol reagent (Life Technologies, Gaithersburg, MD) and purified with RNeasy Mini Kit (Q...
ORGANISM(S): Homo sapiens 
2007-08-14 | E-GEOD-1729 | biostudies-arrayexpress
TranscriptomicsRestoration of miR-214 expression reduces cell growth of myeloma cells through a positive regulation of P53 and inhibition of DNA replication
MicroRNAs have been demonstrated to be deregulated in multiple myeloma (MM). We have previously reported the downregulation of miR-214 in MM compared to normal plasma cells. In the present study, we have explored the functional role of miR-214 in myeloma pathogenesis. Ectopic expression of miR-214 r...
ORGANISM(S): Homo sapiens 
2012-12-28 | E-GEOD-35948 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of endometrial biopsies inflammatory response to Chlamydia trachomatis genital tract infection
Chlamydia trachomatis is an obligate intracellular Gram-negative bacterium that frequently causes an asymptomatic genital tract infection, gradually cleared by host immunity Transcriptome profiles were made of endometrial tissue from women with or without genital tract C. trachomatis infection, to c...
ORGANISM(S): Homo sapiens 
2013-03-01 | E-GEOD-41075 | biostudies-arrayexpress
UnknownProspective evaluation of the conversion rate in the receptor status between primary breast cancer and metastasis: results from the GEICAM 2009-03 ConvertHER study.
Not available
S-EPMC3907670 | biostudies-literature
UnknownA phase I safety and efficacy clinical trial of plocabulin and gemcitabine in patients with advanced solid tumors.
Not available
S-EPMC11625058 | biostudies-literature
TranscriptomicsGene expression profiling of B lymphocytes and plasma cells from Waldenstrons macroglobulinemia.
The tumoral clone of Waldenstrons macroglobulinemia (WM) shows a wide morphological heterogeneity which ranges from B-lymphocytes (BL) to plasma cells (PC). By means of genome-wide expression profiling we have been able to identify genes exclusively deregulated in BL and PC from WM, but with a simil...
ORGANISM(S): Homo sapiens 
2007-03-01 | E-GEOD-6691 | biostudies-arrayexpress
TranscriptomicsPhenotypic, transcriptomic and genomic characterization of clonal plasma cells in light chain amyloidosis [Gene expression profiling]
Immunoglobulin light-chain amyloidosis (AL) is a rare clonal plasma cell (PC) disorder that remains largely incurable. AL and multiple myeloma (MM) share the same cellular origin, but while knowledge about MM PC biology has improved significantly, the same does not apply for AL. Here, we undertook a...
ORGANISM(S): Homo sapiens 
2016-07-22 | E-GEOD-73040 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of macrophages from Familial Hypercholesterolemia(FH) patients with tendon xanthomas (TX+) and without tendon xanthomas (TX-) to evaluate the gene expression profile in presence and absence of oxidized LDL
Total RNA pools from macrophages from Familial Hypercholesterolemia(FH) patients with tendon xanthomas (TX+) and without tendon xanthomas (TX-) were analyzed using Affymetrix oligonucleotide arrays (HGU133A) to evaluate the gene expression profile in presence and absence of oxidized LDL.
ORGANISM(S): Homo sapiens 
2006-01-01 | E-MEXP-360 | biostudies-arrayexpress
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