Sort   by:  
 Page size 
TranscriptomicsMedial HOXA gene expression is a landmark for the definitive haematopoietic fate and a prerequisite for human HSC function
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-05-16 | E-GEOD-76685 | biostudies-arrayexpress
GenomicsScl specifies hemogenic endothelium and inhibits cardiogenesis via primed enhancers [RRBS]
Scl/Tal1 confers hemogenic competence and prevents cardiomyogenesis in embryonic endothelium. Here we show that Scl both directly activates a broad gene regulatory network required for hematopoietic stem/progenitor cell (HS/PC) development, and represses transcriptional regulators required for cardi...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-56359 | biostudies-arrayexpress
GenomicsScl specifies hemogenic endothelium and inhibits cardiogenesis via primed enhancers [ChIP-seq]
Scl/Tal1 confers hemogenic competence and prevents cardiomyogenesis in embryonic endothelium. Here we show that Scl both directly activates a broad gene regulatory network required for hematopoietic stem/progenitor cell (HS/PC) development, and represses transcriptional regulators required for cardi...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-47082 | biostudies-arrayexpress
TranscriptomicsSelective suppression of endothelial cytokine production by progesterone receptor [RNA-seq]
Steroid hormones are well-recognized suppressors of the inflammatory response, however, their cell- and tissue-specific effects in the regulation of inflammation are far less understood, particularly for the sex-related steroids. To determine the contribution of progesterone in the endothelium, we h...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-GEOD-46502 | biostudies-arrayexpress
GenomicsPhysiological Vascular Permeability Requires Induction of Endothelial NR4A1 by Progesterone Receptor [ChIP-Seq]
Vascular permeability is frequently associated with inflammation and it is triggered by chemokines and by a cohort of secreted permeability factors, such as VEGF. In contrast, here we showed that the physiological vascular permeability that precedes implantation is directly controlled by progestero...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-GEOD-43786 | biostudies-arrayexpress
TranscriptomicsExpression data from immunophenotypic HSPCs isolated from different stages of human hematopoiesis, in vivo and in vitro
The derivation of functional, transplantable HSCs from an pluripotent stem cells in vitro holds great promise for clinical therapies, but is unachieved. In order to achieve full functionality of HSCs, it is vital to determine the extent to which PSCs can currently be differentiated to the HSC progra...
ORGANISM(S): Homo sapiens 
2016-05-16 | E-GEOD-64865 | biostudies-arrayexpress
TranscriptomicsScl specifies hemogenic endothelium and inhibits cardiogenesis via primed enhancers
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-47085 | biostudies-arrayexpress
TranscriptomicsRNA-seq expression data from EB-HSPC after AM580 treatment compated to DMSO-trated and FL-HSPCs
RA signalling regulated endothelial to hematopoietic transition and HSC generation. EB- or FL-derived HSPC were profiled before (d0) or after (d6) 6 days of treatment with 0.2uM AM580 on OP9, and after 6 additional days of expandion of OP9 (d12) without treatment.
ORGANISM(S): Homo sapiens 
2016-05-16 | E-GEOD-76682 | biostudies-arrayexpress
TranscriptomicsRNA-seq expression data from EB-HSPCs after HOXA7 overexpression
HOXA7 regulates FL-HSPC self-renewal in vitro and in vivo. We profiled EB-HSPCs after HOXA7 overexpression (EB-HOXA7), or with a control vector (EB-CTR), to assess the gene expression programs regulated by HOXA7. CD34+CD38-CD43+CD90+ HSPCs were infected with lentiviral FUGW vector either empty (FUG...
ORGANISM(S): Homo sapiens 
2016-05-16 | E-GEOD-76684 | biostudies-arrayexpress
TranscriptomicsScl specifies hemogenic endothelium and inhibits cardiogenesis via primed enhancers [expression]
Scl/Tal1 confers hemogenic competence and prevents cardiomyogenesis in embryonic endothelium. Here we show that Scl both directly activates a broad gene regulatory network required for hematopoietic stem/progenitor cell (HS/PC) development, and represses transcriptional regulators required for cardi...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-47084 | biostudies-arrayexpress
Sort   by:  
 Page size