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TranscriptomicsModeling oncogenic signaling in colon tumors by multidirectional analyses of microarray data
Background. Most colorectal cancers (CRC) arise in a progression through adenoma to carcinoma phenotypes as a consequence of altered genetic information. Clinical progression of CRC may occur in parallel with distinctive signaling alterations. We designed multidirectional analyses integrating microa...
ORGANISM(S): Homo sapiens 
2010-08-01 | E-GEOD-20916 | biostudies-arrayexpress
ProteomicsPD-L1 overexpression, SWI/SNF complex Deregulation and Profound Transcriptomic Changes Characterize Cancer-Dependent Exhaustion of Persistently Activated CD4+ T Cells
The growing tumor avoids recognition and destruction by immune system. During continuous stimulation of tumor infiltrating lymphocytes (TILs) by tumor, TILs become functionally exhausted. Thus, they become unable to kill tumor cells and to produce some cytokines, and lose their ability to proliferat...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2022-02-17 | PXD026447 | Pride
Cd4+ effector t cells  t cell exhaustion  swi/snf complex  pd-1  pd-l1  pd-l1/pd-1 axis 
ProteomicsProtein expression in TKI-resistant RCC cells.
Resistance to tyrosine kinase inhibitors is an essential issue concerning targeted therapy in renal cancer. This research focuses on molecular background of resistance to axitinib and sorafenib observed from the very beginning of a standard two-dimensional cell culture in monolayer as well as in thr...
ORGANISM(S): Homo sapiens (Human) 
2018-01-02 | PXD002600 | Pride
Kidney cancer Stem cell Mass spectrometry Label free 
TranscriptomicsProx1 (Prosper-related homeobox 1) transcription factor depletion effect on CGTH-W-1 cells.
Analysis of CGTH-W-1 follicular thyroid carcinoma cells transcriptome following 48 hrs siRNA-mediated depletion of PROX1. PROX1 is a homeobox transcription factor. PROX1 depletion decreases migratory ability, motility and invasivness and induces profound cytoskeleton changes of CGTH-W-1 cells. ...
ORGANISM(S): Homo sapiens 
2016-07-31 | E-GEOD-80135 | biostudies-arrayexpress
GenomicsGenome wide extracellular signal-regulated kinase (ERK) pathway components interaction with human genome
Several recent studies, including ours, show that most components of signal transduction cascades including the extracellular signal-regulated protein kinase (ERK), that once were thought to act predominantly in cytoplasm, are in fact recruited to chromatin and are integral components of transcript...
ORGANISM(S): Homo sapiens 
2015-08-01 | E-GEOD-65323 | biostudies-arrayexpress
TranscriptomicsDNA methylation sensitivity at detecting cancer in prostate core biopsies [DNA Methylation Profiles]
The aim of this study was to analyze critically the potential usefulness of selected DNA methylation biomarkers in supporting conventional histological diagnostic tests for PCa. The selection of potential biomarkers was conducted by microarray profiling of DNA methylation on prostate tissues extract...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-55598 | biostudies-arrayexpress
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