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TranscriptomicsCardiac Gene Expression Profiling in CryAB R120G Transgenic Mice
Protein aggregation cardiomyopathy is a life-threatening manifestation of a multisystem disorder caused by the exchange mutation in the gene encoding the human small HSP ?B-crystallin (hR120GCryAB). Genetic studies in mice have established cardiac hR120GCryAB expression causes increased activity of...
ORGANISM(S): Mus musculus 
2008-12-12 | E-GEOD-9924 | biostudies-arrayexpress
TranscriptomicsThe Dynamic Transcriptome of Schizosaccharomyces pombe Revealed by RNA/DNA Hybrid Mapping
We determined the strand-specific transcriptome of the fission yeast S. pombe under multiple growth conditions using a novel RNA/DNA hybridization mapping (HybMap) technique. HybMap uses an antibody against an RNA/DNA hybrid to detect RNA molecules hybridized to a high density DNA oligonucleotide ti...
ORGANISM(S): Schizosaccharomyces pombe 
2008-06-29 | E-GEOD-11619 | biostudies-arrayexpress
TranscriptomicsZinc-dependent regulation of the adh1 antisense transcript in fission yeast
In yeast, alcohol dehydrogenase I (Adh1) is an abundant zinc binding protein that is required for the conversion of acetaldehyde to ethanol. Through transcriptome profiling of the Schizosaccharomyces pombe genome, we identified a natural antisense transcript at the adh1 locus that is induced in resp...
ORGANISM(S): Schizosaccharomyces pombe 
2012-12-12 | E-GEOD-39701 | biostudies-arrayexpress
TranscriptomicsRegulation by the homologous Ace2 and Swi5 factors of Saccharomyces cerevisiae
The homologous Ace2 and Swi5 transcription factors of Saccharomyces cerevisiae have identical DNA-binding domains, and both are cell cycle regulated. There are common target genes, as well as genes activated only by Ace2 and other genes activated only by Swi5. Keywords: genetic modification RNA was ...
ORGANISM(S): Saccharomyces cerevisiae 
2008-05-13 | E-GEOD-11380 | biostudies-arrayexpress
TranscriptomicsPrimary Mammary Epithelial Cells: Control vs 1023-Treated
Gene expression profiling of primary mammary epithelial cells treated for 72 hours with compound 1023 compared to DMSO. Goal was to determine genes differntially regulated by treatment with the novel compound, 1023. Two-condition experiment, DMSO vs. 1023. Biological replicates: 2 control replicate...
ORGANISM(S): Mus musculus 
2012-12-31 | E-GEOD-39249 | biostudies-arrayexpress
TranscriptomicsTranscriptome sequencing and microarray development for the woodrat (Neotoma spp.): custom genetic tools for exploring herbivore ecology
We present the de novo transcriptome sequencing, analysis and microarray development for a vertebrate herbivore, the woodrat (Neotoma spp.). This genus is of ecological and evolutionary interest, especially with respect to ingestion and hepatic metabolism of potentially toxic plant secondary compoun...
ORGANISM(S): Neotoma bryanti 
2013-07-30 | E-GEOD-43941 | biostudies-arrayexpress
TranscriptomicsTransformation of enriched mammary cell populations with Polyoma Middle T Antigen influences tumor subtype and metastatic potential
Breast cancer is a multifaceted disease, exhibiting significant molecular, histological, and pathological diversity. Factors that impact this heterogeneity are poorly understood; however, transformation of distinct normal cell populations of the breast may generate different tumor phenotypes. Our pr...
ORGANISM(S): Mus musculus 
2015-09-08 | E-GEOD-64453 | biostudies-arrayexpress
TranscriptomicsAntibody detection of translocations (ADOT) in Ewing Sarcoma
We developed a new approach called antibody detection of translocations (ADOT) which combines a transcriptional microarray-based approach with a novel antibody-based detection method to detect translocations in cancer. ADOT allows for the accurate and sensitive identification of translocations and p...
ORGANISM(S): Homo sapiens 
2012-01-31 | E-GEOD-35450 | biostudies-arrayexpress
TranscriptomicsThe polycomb repressive complex PRC2 regulates proliferation and neurogenesis in the Xenopus retina, and is governed by Wnt/beta-catenin signaling
The histone methyltransferase complex PRC2 controls key steps in developmental transitions and cell fate choices. However, its roles in vertebrate eye development remain unknown. Here we report that in Xenopus PRC2 regulates the progression of retinal progenitors from proliferation to differentiatio...
ORGANISM(S): Xenopus laevis 
2013-05-30 | E-GEOD-47456 | biostudies-arrayexpress
TranscriptomicsTargeting PyMT oncogene to diverse mammary cell populations enhances tumor heterogeneity and generates rare breast cancer subtypes
Generating a new mouse model for breast cancer heterogenaity. We use lentiviral infection to integrate the sporatically transforming EF1α-PyMT10C or Muc-PyMT10C into mouse mammary epithelial cell genomes. We then transplant those cells into cleared mammary fat pads of recipient mice, allowing tumors...
ORGANISM(S): Mus musculus 
2012-08-09 | E-GEOD-40001 | biostudies-arrayexpress
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