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MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
TranscriptomicsHuman iPSC-based Modeling of Late-Onset Disease using Progerin-induced Aging
Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) sets their identity back to an embryonic age. This presents a fundamental hurdle for modeling late-onset disorders using iPSC-derived cells. We therefore developed a strategy to induce age-like features in multiple iPSC-derived li...
ORGANISM(S): Homo sapiens 
2014-01-23 | E-GEOD-52431 | biostudies-arrayexpress
UnknownVitamin D receptor gene as a candidate gene for Parkinson disease.
Not available
S-EPMC3077063 | biostudies-literature
TranscriptomicsSystematic meta-analysis and replication of genome-wide expression studies of Parkinson's disease: 2
Systematic meta-analysis and replication of genome-wide expression studies identifies molecular pathways of Parkinson's disease. Examination of substantia nigra from postmortem brains of 8 patients with Parkinson's disease (PD). The substantia nigra samples from 8 PD subjects were obtained from the ...
ORGANISM(S): Homo sapiens 
2011-01-20 | E-GEOD-20163 | biostudies-arrayexpress
MetabolomicsSex differences modulate blood metabolome profiles in Parkinson’s disease patients harbouring rare genetic variants

Background: Recent findings from our group indicate that sex differences in Parkinson's disease (PD) patients with idiopathic conditions or carrying pathogenic mutations significantly influence the blood occurrence of D and L-amino acids, lipids, antioxidants, and energy-related metabolites when ...

2026-06-26 | MTBLS12746 | MetaboLights
TranscriptomicsExpression analysis of laser-dissected SNpc neurons in Parkinson's disease
Genome-wide transcriptome analysis of expression changes in laser-dissected SNpc neurons from Parkinson's disease brain tissue versus control brain tissue. Post-mortem brain expression analysis performed in 10 PD brain samples and 8 control brain samples.
ORGANISM(S): Homo sapiens 
2010-02-22 | E-GEOD-20141 | biostudies-arrayexpress
UnknownDNA variants in CACNA1C modify Parkinson disease risk only when vitamin D level is deficient.
Not available
S-EPMC4830205 | biostudies-literature
UnknownAssociation of the prognostic model iSEND with PD-1/L1 monotherapy outcome in non-small-cell lung cancer.
Not available
S-EPMC7000664 | biostudies-literature
TranscriptomicsSystematic meta-analysis and replication of genome-wide expression studies identifies molecular pathways of Parkinson’s disease
Analysis of human dopamine (DA) from postmortem brains of 8 patients with Parkinson’s disease (PD). Results provide insight into the molecular processes perturbed in the PD substantia nigra. Human dopamine (DA) neurons from 8 PD and 9 control subjects were obtained. Double-stranded complementary DNA...
ORGANISM(S): Homo sapiens 
2011-01-20 | E-GEOD-24378 | biostudies-arrayexpress
UnknownConsidering sex as a biological variable in preclinical research.
Not available
S-EPMC6191005 | biostudies-literature
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