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TranscriptomicsATACseq: STAT1 and STAT3 transcription factors sense and interpret changes in inflammation through engagement of specific enhancers
To investigate how chromatin is shaped during inflammation geared towards the development of fibrosis in peritoneal tissue, we performed ATAC-seq in peritoneal membranes from wt and Il-6 knockout mice challenged with SES (a lyophilized cell-free supernatant prepared from Staphylococcus epidermidis )...
ORGANISM(S): Mus musculus 
2022-04-04 | E-MTAB-10739 | biostudies-arrayexpress
GenomicsChIP seq: STAT1 and STAT3 transcription factors sense and interpret changes in inflammation through engagement of specific enhancers
Using ChIP-Seq analysis we explore regulation of gene expression changes during inflammatory peritonitis induced by challenge with bacterial ligands administered via the intra-peritoneal route. A resuspended lypholised supernatant of Staphylococcus epidermidis (SES) was administered with or without ...
ORGANISM(S): Mus musculus 
2022-04-04 | E-MTAB-10758 | biostudies-arrayexpress
TranscriptomicsRNA-seq: STAT1 and STAT3 transcription factors sense and interpret changes in inflammation through engagement of specific enhancers
To investigate potential changes in the provision of competent host defence versus inflammation-induced tissue injury, we used RNA-seq to profile gene signatures in ‘resolving’ and ‘pro-fibrotic’ peritoneal lining tissues. We performed RNA-seq in peritoneal membranes from WT and IL6KO mice challenge...
ORGANISM(S): Mus musculus 
2022-04-04 | E-MTAB-10087 | biostudies-arrayexpress
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