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ModelsMuller2008 - Simplified MAPK activation Dynamics (Model B)
Muller2008 - Simplified MAPK activation Dynamics (Model B) Simplified mathematical model (model B) for predicting MAPK signal expression. This model is described in the article: Network topology determines dynamics of the mammalian MAPK1,2 signaling network: bifan motif regulation...
2024-09-02 | BIOMD0000000664 | BioModels
TranscriptomicsAutotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice
Brown adipose tissue (BAT) is a thermogenic organ that dissipates stored energy as heat to maintain body temperature in infants and small mammals. This process may also provide protection from development of diet-induced obesity. We found that the bioactive lipid mediator lysophosphatidic acid (LP...
ORGANISM(S): Mus musculus 
2011-06-01 | E-GEOD-26442 | biostudies-arrayexpress
TranscriptomicsEffect of a dual specificity PI3K/mTOR inhibitor, NVP-BEZ235, on human ovarian cancer cell lines grown in 3D culture
Analysis of the effects of a dual specificity PI3K/mTOR inhibitor on two human ovarian cell lines, OV2008 and MCAS. Results provide insight into the adaptive response to PI3K/mTOR inhibition in matrix attached ovarian cancer cells. The PI3K/mTOR-pathway is the most commonly deregulated pathway in e...
ORGANISM(S): Homo sapiens 
2012-03-13 | E-GEOD-28992 | biostudies-arrayexpress
TranscriptomicsAn integromic analysis reveals that metaplastic carcinomas are distinct from basal-like tumors.
Metaplastic breast cancers (MBC) are aggressive, chemoresistant tumors characterized by lineage plasticity. To advance understanding of their pathogenesis and relatedness to other breast cancer subtypes, 28 MBCs were compared with common breast cancers using comparative genomic hybridization, transc...
ORGANISM(S): Homo sapiens 
2009-04-01 | E-GEOD-10885 | biostudies-arrayexpress
TranscriptomicsGene profiles induced by overexpression of wild-type and mutant Notch1 variants in MCF10A mammary epithelial cell line
Expression of a constitutively active Notch-1 intracellular domain (NICD) in MCF-10A cells was found to induce two distinct types of 3D structures: large, hyperproliferative structures and small, growth-arrested structures with reduced cell-to-matrix adhesion. These heterogeneous phenotypes reflect...
ORGANISM(S): Homo sapiens 
2010-03-23 | E-GEOD-20285 | biostudies-arrayexpress
GenomicsWhole-exome Sequencing Combined with Functional Genomics Reveals Novel Candidate Driver Cancer Genes in Endometrial Cancer
Endometrial cancer is the most common gynecological malignancy, with more than 280,000 cases occurring annually worldwide. Although previous studies have identified important common somatic mutations in endometrial cancer, they have primarily focused on a small set of known cancer genes and have thu...
EGAS00001000318 | EGA
ProteomicsTumor and adjacent normal tissue
Proteome characterization of 5 breast tumors and adjacent normal tissue using HiRIEF nanoLC-MS/MS.
ORGANISM(S): Homo Sapiens (human) 
2019-02-04 | PXD011385 | JPOST Repository
ProteomicsBreast cancer proteome landscape
Proteome characterization of 45 breast tumors using HiRIEF nanoLC-MS/MS.
ORGANISM(S): Homo Sapiens (human) 
2019-02-04 | PXD008841 | JPOST Repository
Genomicsena-DATASET-MDACC-22-07-2012-17:29:58:085-32 - samples
MDACC-endo
EGAD00001000201 | EGA
GenomicsMDACC-endo
Data Access Committee EGAC00001000066
EGAC00001000066 | EGA
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