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TranscriptomicsRNA-Seq of human K-562 leukaemia cell line with and without K700E mutation in coding region of SF3B1 gene
The aim of this experiment was to compare the transcriptomes of SF3B1 mutant and wildtype isogenic cells at the whole cell, nuclear and cytoplasmic levels. Mutations in SF3B1 are often found in the malignant cells of patients suffering from myelodysplastic syndromes and more rarely in other cancer t...
ORGANISM(S): Homo sapiens 
2019-02-25 | E-MTAB-7192 | biostudies-arrayexpress
UnknownA "Beheaded" TAML Activator: A Compromised Catalyst that Emphasizes the Linearity between Catalytic Activity and pKa.
Not available
S-EPMC5479581 | biostudies-literature
UnknownPolycomb protein RING1A limits hematopoietic differentiation in myelodysplastic syndromes.
Not available
S-EPMC5777749 | biostudies-literature
TranscriptomicsExpression data of Low-Risk Myelodysplastic Syndromes (MDSs)
Genome-wide expression and methylation profiling identifies novel targets with aberrant hypermethylation and reduced expression in low-risk myelodysplastic syndromes (MDSs). Gene expression profiling signatures may be used to classify the subtypes of Myelodysplastic syndrome (MDS) patients. However,...
ORGANISM(S): Homo sapiens 
2012-09-25 | E-GEOD-41130 | biostudies-arrayexpress
TranscriptomicsMethylation profiling of Low-Risk Myelodysplastic Syndromes (MDSs)
Genome-wide expression and methylation profiling identifies novel targets with aberrant hypermethylation and reduced expression in low-risk myelodysplastic syndromes (MDSs). Gene expression profiling signatures may be used to classify the subtypes of Myelodysplastic syndrome (MDS) patients. However,...
ORGANISM(S): Homo sapiens 
2012-09-28 | E-GEOD-41215 | biostudies-arrayexpress
TranscriptomicsAutotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice
Brown adipose tissue (BAT) is a thermogenic organ that dissipates stored energy as heat to maintain body temperature in infants and small mammals. This process may also provide protection from development of diet-induced obesity. We found that the bioactive lipid mediator lysophosphatidic acid (LP...
ORGANISM(S): Mus musculus 
2011-06-01 | E-GEOD-26442 | biostudies-arrayexpress
UnknownA comprehensive validation of very early rule-out strategies for non-ST-segment elevation myocardial infarction in emergency departments: protocol for a multicentre prospective cohort study.
Not available
S-EPMC6731951 | biostudies-literature
UnknownComprehensive validation of early diagnostic algorithms for myocardial infarction in the emergency department.
Not available
S-EPMC10972704 | biostudies-literature
TranscriptomicsHIP1 mediates prostate carcinogenesis and progression through STAT3 signalling
Overexpression of HIP1 has been associated with fibroblast transformation, increasing grades of prostate cancer (CaP), and biochemical relapse. Here we demonstrate cellular transformation and phenotypic effects of HIP1 overexpression in a benign prostate epithelial cell line to be dependent on STAT3...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-35211 | biostudies-arrayexpress
TranscriptomicsGenome-wide profiling of methylation identifies novel targets with aberrant hypermethylation and reduced expression in low-risk myelodysplastic syndromes.
This SuperSeries is composed of the following subset Series: GSE41130: Expression profiling of Low-Risk Myelodysplastic Syndromes (MDSs) GSE41215: Methylation profiling of Low-Risk Myelodysplastic Syndromes (MDSs) Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-09-28 | E-GEOD-41216 | biostudies-arrayexpress
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