Sort   by:  
 Page size 
GenomicsRUNX1 is a key target gene in t(4;11) leukemias and contributes to gene activation by interacting with the AF4-MLL complex
The Mixed Lineage Leukemia 1 protein (MLL1) is an important epigenetic regulator required for the maintenance of gene activation during development. MLL1 chromosome translocations produce novel fusion proteins that cause aggressive leukemias in humans. Individual MLL1 fusion proteins have distinct l...
ORGANISM(S): Homo sapiens 
2013-01-31 | E-GEOD-42075 | biostudies-arrayexpress
GenomicsIntegrative Epigenomic Analysis Identifies Biomarkers and Therapeutic Targets in Adult B-Acute Lymphoblastic Leukemia [ChIP-seq]
Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia. We performed DNA methylation (HELP array) and gene expression profiling in 215 samples of adult B-lineage acute lymphoblastic leukemia (ALL) and 12 normal preB samples. Adult B-lin...
ORGANISM(S): Homo sapiens 
2012-11-27 | E-GEOD-38403 | biostudies-arrayexpress
GenomicsBase-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in Acute Myeloid Leukemia
Here we used Illumina NGS for high-throughput profiling of the DNA methylome in two human colon cancer derived cell lines, two human normal bone marrow CD34+ controls and in five human Acutre Myeloid Leukeima patient samples. These data can be used to determine the CpG cytosine methylation pattern ...
ORGANISM(S): Homo sapiens 
2012-06-01 | E-GEOD-37454 | biostudies-arrayexpress
UnknownMutate and Conjugate: A Method to Enable Rapid In-Cell Target Validation.
Not available
S-EPMC10660337 | biostudies-literature
UnknownThe MLH1 polymorphism rs1800734 and risk of endometrial cancer with microsatellite instability.
Not available
S-EPMC7346630 | biostudies-literature
UnknownPROM1/CD133 marks a proliferative stem cell-like population of blasts in KMT2A rearranged infant ALL.
Not available
S-EPMC12455107 | biostudies-literature
UnknownAssociation of British Clinical Diabetologists and UK Kidney Association Joint Clinical Practice Guidelines for the Pharmacological Management of Hyperglycemia in Adults With Type 2 Diabetes Mellitus and CKD.
Not available
S-EPMC12545811 | biostudies-literature
UnknownOff-the-shelf dual CAR-iNKT cell immunotherapy eradicates medullary and leptomeningeal high-risk KMT2A-rearranged leukemia.
Not available
S-EPMC12824662 | biostudies-literature
UnknownMLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199.
Not available
S-EPMC4700051 | biostudies-literature
Unknown9q31.2-rs865686 as a susceptibility locus for estrogen receptor-positive breast cancer: evidence from the Breast Cancer Association Consortium.
Not available
S-EPMC3772723 | biostudies-literature
Sort   by:  
 Page size