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MetabolomicsMechanistic insights into the biological activity of S-Sulfocysteine in CHO cells using a multi-omics approach
S-Sulfocysteine (SSC), a bioavailable L-cysteine derivative (Cys), is known to be taken up and metabolized in Chinese hamster ovary (CHO) cells used to produce novel therapeutic biological entities. To gain a deeper mechanistic insight into the SSC biological activity and metabolization, a multi-omi...
2024-08-08 | MTBLS7424 | MetaboLights
TranscriptomicsMolecular Analysis of the Genes Involved in Aroma Synthesis in the Species S. cerevisiae, S. kudriavzevii and S. bayanus var. uvarum in Winemaking
This research work investigates the hybridization of the genes of Saccharomyces bayanus var. uvarum CECT 12600 and S. kudriavzevii IFO1802 employing S. cerevisiae microarrays. Two strains,one S. kudriavzevii and one S. bayanus var. uvarum were employed for the study. The S. cerevisiae strain S288C w...
ORGANISM(S): Saccharomyces uvarum 
2014-06-23 | E-GEOD-52446 | biostudies-arrayexpress
ProteomicsA protein microarray-based analysis of S-nitrosylation
Yeast protein microarrays were utilized to investigate determinants of S-nitrosylation by biologically relevant low-mass S-nitrosothiols (SNOs). Large numbers of S-nitrosylated yeast proteins were identified after treatment with SNOs, among which those with active-site Cys thiols residing at N termi...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-19 | E-GEOD-19218 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of cyanophage S-PM2 as it infects Synechococcus WH7803 over a 9 hr time series
To monitor the expression of cyanophage S-PM2 genes as it infects Synechococcus WH7803 over a 9 hr time course. Samples were take from 3 independent cultures. A reference design was used with dye swaps (technical replicates) for each time point.
ORGANISM(S): Synechococcus phage S-PM2 
2009-10-01 | E-MAXD-26 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of MLL5 Knock down vs. control C2C12 myoblasts (S phase enriched)
Knockdown of MLL5 led to deregulation of S phase. To understand the molecular basis for this phenotype, we performed microarray analysis of S phase synchronized myoblasts. Genes differentially regulated by MLL5 knock down were revealed by microarray analysis using NIA15K mouse chips. Control and kno...
ORGANISM(S): Mus musculus 
2010-05-22 | E-GEOD-14931 | biostudies-arrayexpress
MetabolomicsGluconeogenic enzyme PCK1 supports S-adenosylmethionine biosynthesis and H3K9me3 to suppress HCC progression
Deciphering the crosstalk between metabolic reprogramming and epigenetic regulation is a promising strategy for cancer therapy. In this study, we discovered that the gluconeogenic enzyme PCK1 fuels the generation of S-adenosylmethionine (SAM) through the serine synthesis pathway. The methyltransfera...
2025-08-09 | MTBLS7651 | MetaboLights
TranscriptomicsTranscription profiling of S. cerevisiae T128 was used as a model of typical commercial bakers yeast used in Japan to investigation of stress responses during commercial fermentation
Gene expression profiles of baker’s yeast during initial dough-fermentation were investigated using liquid fermentation media to obtain insights at the molecular level into rapid adaptation mechanisms of baker’s yeast. Results showed that onset of fermentation caused drastic changes in gene expr...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-12 | E-GEOD-3043 | biostudies-arrayexpress
GenomicsCricetulus griseus strain:CHO-S
Transcriptome of cultured CHO-S cells
PRJDB6126 | ENA
TranscriptomicsTranscription profiling of S. pombe reveals Cyclin dependent kinase inhibits re-initiation of a normal S-phase program during G2
To achieve faithful replication of the genome once in each cell cycle, re-initiation of S-phase is prevented in G2 and origins are restricted from re-firing within S-phase. We have investigated the block to re-replication during G2 in fission yeast. The DNA synthesis that occurs when G2/M cyclin d...
ORGANISM(S): Schizosaccharomyces pombe 
2009-05-13 | E-MTAB-105 | biostudies-arrayexpress
ProteomicsChromatin-associated proteome S. cerevisiae
Chromatin-associated and RNA-dependent Chromatin-associated proteome from S. cerevisiae, obtained by a new method yChEFs(yeast Chromatin Enriched Fractions)
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-07-17 | PXD009264 | Pride
Processing Rna Chromatin S. cerevisiae 
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