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MetabolomicsMetabolic memory underlying minimal residual disease in breast cancer

Tumor relapse from treatment-resistant cells (minimal residual disease, MRD) underlies most breast cancer related deaths. Yet, the molecular characteristics defining their malignancy have largely remained elusive. Here we integrated multi-omics data from a tractable organoid system with a metabol...

2021-09-14 | MTBLS1507 | MetaboLights
TranscriptomicsLinking genomic lesions with minimal residual disease improves prognostic stratification in children with T-cell acute lymphoblastic leukaemia
GEP class prediction in association with CI-FISH (42 candidate genes) and patient MRD stratification Combined Interphase FISH (CI-FISH) for 42 candidate genes and Single Nucleotide Polymorphism (SNP) arrays were applied in a series of 51 T-ALL patients enrolled in Italy into the AIEOP-BFM ALL2000 pr...
ORGANISM(S): Homo sapiens 
2013-11-05 | E-GEOD-39816 | biostudies-arrayexpress
GenomicsCirculating Tumor DNA Analysis Detects Minimal Residual Disease and Predicts Recurrence in Patients with Stage II Colon Cancer
Detection of circulating tumor DNA (ctDNA) after resection of stage II colon cancer may identify those at the highest risk of recurrence and help inform adjuvant treatment decisions. We used massively-parallel-sequencing–based assays to evaluate the ability of ctDNA to detect minimal residual diseas...
EGAS00001001839 | EGA
GenomicsEnzymatic Methyl-seq (EM-seq) of doxycycline induced tumor and residual mouse primary mammary epithelial cells grown in 3D cell cultures against non-induced controls
This experiment investigates the genome wide DNA methylation landscape of residual breast cancer cells. Primary mammary epithelial cells taken from female mice with doxycycline-inducible hMyc- and Neu/Her2-oncogenes were grown in 3D organoid cultures. Upon the addition of doxycycline (200ng/mL) to t...
ORGANISM(S): Mus musculus 
2021-10-03 | E-MTAB-10979 | biostudies-arrayexpress
TranscriptomicsRNA-seq of doxycycline induced tumor and residual mouse primary mammary epithelial cells grown in 3D cell cultures against non-induced controls
This experiment investigates the expression characteristics of residual breast cancer cells. Primary mammary epithelial cells taken from female mice with doxycycline-inducible hMyc- and Neu/Her2-oncogenes were grown in 3D organoid cultures. Upon the addition of doxycycline (200ng/mL) to the medium t...
ORGANISM(S): Mus musculus 
2020-12-31 | E-MTAB-8834 | biostudies-arrayexpress
GenomicsMinimal Residual Disease in Mouse Hepatocellular carcinoma [in vivo]
Minimal Residual Disease in Mouse Hepatocellular carcinoma [in vivo]
PRJNA1014440 | ENA
GenomicsTowards minimal residual disease-directed therapy in melanoma
Towards minimal residual disease-directed therapy in melanoma
PRJNA477841 | ENA
TranscriptomicsDNA methylation adds prognostic value to minimal residual disease status in pediatric T-cell acute lymphoblastic leukemia
Background: Despite increased knowledge about genetic aberrations in pediatric T-cell acute lymphoblastic leukemia (T-ALL), no clinically feasible treatment-stratifying marker exists at diagnosis. Instead patients are enrolled in intensive induction therapies with substantial side effects. In modern...
ORGANISM(S): Homo sapiens 
2016-03-30 | E-GEOD-69954 | biostudies-arrayexpress
GenomicsSingle Cell Minimal Residual Disease Analysis in Multiply Relapsed AML Patient
Single Cell Minimal Residual Disease Analysis in Multiply Relapsed AML Patient
PRJNA1132526 | ENA
GenomicsMinimal Residual Disease in Mouse Hepatocellular carcinoma [in vitro]
Minimal Residual Disease in Mouse Hepatocellular carcinoma [in vitro]
PRJNA1014444 | ENA
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