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TranscriptomicsHuman lung epithelial cells progressed to malignancy through specific oncogenic manipulations
We have developed cdk4/hTERT-immortalized normal human bronchial epithelial cells (HBECs) to study lung cancer pathogenesis. By studying the oncogenic effect of common lung cancer alterations (p53, KRAS, and c-MYC) we demonstrate the ability of this model to characterize the stepwise transformation...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-40828 | biostudies-arrayexpress
TranscriptomicsExpression profiling of lung cancer cell lines (UTSW Lung Panel V2)
Epithelial/mesenchymal transition (EMT) is associated with loss of cell adhesion molecules, such as E-cadherin, and increased invasion, migration, and proliferation in epithelial cancers. In non-small cell lung cancer (NSCLC), EMT is associated with greater resistance to EGFR inhibitors. However, it...
ORGANISM(S): Homo sapiens 
2012-10-25 | E-GEOD-32989 | biostudies-arrayexpress
TranscriptomicsExpression profiling of 275 lung cancer specimens
From ~1,700 non-small cell lung cancer specimens collected at the MD Anderson Cancer Center over the years 1997 to 2005, we selected 914 tumors with detailed clinical and pathological information. We extracted RNA and DNA from frozen tissues using histology quality control from 700 cases. RNA was ex...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-41271 | biostudies-arrayexpress
TranscriptomicsAn epithelial-mesenchymal transition (EMT) gene signature predicts resistance to erlotinib and PI3K pathway inhibitors and identifies Axl as a novel EMT marker in non-small cell lung cancer.
Epithelial/mesenchymal transition (EMT) is associated with loss of cell adhesion molecules, such as E-cadherin, and increased invasion, migration, and proliferation in epithelial cancers. In non-small cell lung cancer (NSCLC), EMT is associated with greater resistance to EGFR inhibitors. However, it...
ORGANISM(S): Homo sapiens 
2012-10-25 | E-GEOD-33072 | biostudies-arrayexpress
Genomicsena-DATASET-Genentech-22-08-2012-06:56:27:875-9 - samples
Whole genome sequencing of SCLC tumor/normal samples
EGAD00001000221 | EGA
GenomicsLung normal control - samples
SCLC matched normal genotypes
EGAD00010000278 | EGA
GenomicsSmall Cell Lung Carcinoma - samples
SCLC tumor genotypes
EGAD00010000276 | EGA
Genomicsena-DATASET-Genentech-22-08-2012-07:03:30:871-10 - samples
Exome capture sequencing of SCLC tumor/normal pairs and cell lines
EGAD00001000222 | EGA
Genomicsena-DATASET-Genentech-22-08-2012-07:05:26:504-11 - samples
RNA sequencing of SCLC tumor/normal sample pairs and cell lines
EGAD00001000223 | EGA
GenomicsGenentech Small Cell Lung Cancer (SCLC) Screen
Exome capture, RNA-Seq, whole genome sequencing of set of Small Cell Lung Cancer samples.
EGAS00001000334 | EGA
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