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TranscriptomicsMembers of the microRNA-17-92 cluster exhibit a cell intrinsic anti-angiogenic function in endothelial cells
MicroRNAs are endogenously expressed small non-coding RNAs that regulate gene expression on the posttranscriptional level. The miR-17-92 cluster (encoding miR-17, -18a, -19a/b, -20a and miR-92a) is highly expressed in tumor cells and is up-regulated by ischemia. Whereas miR-92a was recently identifi...
ORGANISM(S): Homo sapiens 
2010-03-23 | E-GEOD-20745 | biostudies-arrayexpress
TranscriptomicsIdentification of miR-4423 as a Primate-Specific microRNA Highly Expressed in Ciliated Airway Epithelium and Associated with Lung Cancer [high throughput sequencing]
Smoking is a significant risk factor for lung cancer, the leading cause of cancer-related deaths worldwide. While microRNAs are regulators of many airway gene-expression changes induced by smoking, their role in modulating changes associated with lung cancer in these cells remains unknown. Here, we ...
ORGANISM(S): Homo sapiens 
2013-10-08 | E-GEOD-32726 | biostudies-arrayexpress
TranscriptomicsIdentification of miR-4423 as a Primate-Specific microRNA Highly Expressed in Ciliated Airway Epithelium and Associated with Lung Cancer [Affymetrix]
Smoking is a significant risk factor for lung cancer, the leading cause of cancer-related deaths worldwide. While microRNAs are regulators of many airway gene-expression changes induced by smoking, their role in modulating changes associated with lung cancer in these cells remains unknown. Here, we ...
ORGANISM(S): Homo sapiens 
2013-10-08 | E-GEOD-48796 | biostudies-arrayexpress
UnknownAn APOA5 3' UTR variant associated with plasma triglycerides triggers APOA5 downregulation by creating a functional miR-485-5p binding site.
Not available
S-EPMC3882731 | biostudies-literature
UnknownCardiomyocyte Lineage Specification in Adult Human Cardiac Precursor Cells Via Modulation of Enhancer-Associated Long Noncoding RNA Expression.
Not available
S-EPMC5916868 | biostudies-literature
MetabolomicsSMN deficiency perturbs monoamine neurotransmitter metabolism in spinal muscular atrophy

Beyond motor neuron degeneration, homozygous mutations in the survival motor neuron 1 (SMN1) gene cause multiorgan and metabolic defects in patients with spinal muscular atrophy (SMA). However, the precise biochemical features of these alterations and the age of onset in the brain and peripheral ...

2023-11-27 | MTBLS8784 | MetaboLights
UnknownFeedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth.
Not available
S-EPMC4981543 | biostudies-literature
UnknownDiagnostic Value of Cell-free Circulating MicroRNAs for Obesity and Type 2 Diabetes: A Meta-analysis.
Not available
S-EPMC4905583 | biostudies-literature
TranscriptomicsIdentification of a set of miRNAs differentially expressed in transiently TIA-depleted HeLa cells by genome-wide profiling
Background: T-cell intracellular antigen (TIA) proteins function as regulators of cell homeostasis. These proteins control gene expression globally at multiple levels in response to dynamic regulatory changes and environmental stresses. Herein we identified a micro(mi)RNA signature associated to tra...
ORGANISM(S): Homo sapiens 
2013-02-06 | E-GEOD-41213 | biostudies-arrayexpress
UnknownmiRNA-375 a Sensor of Glucotoxicity Is Altered in the Serum of Children with Newly Diagnosed Type 1 Diabetes.
Not available
S-EPMC4895032 | biostudies-literature
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