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Metabolomics13C glucose labelling studies using 2D NMR is a useful tool for determining ex vivo whole organ metabolism during hypothermic machine perfusion of kidneys
Background: The aim of this study is to determine the feasibility of using Nuclear Magnetic Resonance (NMR) tracer studies (13C-enriched glucose) to detect ex vivo de novo metabolism in the perfusion fluid and cortical tissue of porcine kidneys during hypothermic machine perfusion (HMP). Methods: Po...
2017-10-16 | MTBLS367 | MetaboLights
MetabolomicsAnalysis of sex-specific lipid metabolism of Plasmodium falciparum points to the importance of sphingomyelin for gametocytogenesis
Male and female Plasmodium falciparum gametocytes are the parasite lifecycle stage responsible for transmission of malaria from the human host to the mosquito vector. Not only are gametocytes able to survive in radically different host environments, but they are also precursors for male and female g...
2022-04-05 | MTBLS4137 | MetaboLights
TranscriptomicsA High-Fat Diet and NAD+ Rescue Premature Aging in Cockayne Syndrome
Cockayne syndrome (CS) is an accelerated aging disorder characterized by progressive neurodegeneration caused by mutations in the genes encoding the DNA repair proteins CSA or CSB. Csbm/m mice were given a high-fat, caloric-restricted or resveratrol-supplemented diet. The high-fat diet rescued the p...
ORGANISM(S): Mus musculus 
2014-12-22 | E-GEOD-62194 | biostudies-arrayexpress
UnknownIn vivo hippocampal subfield volumes in bipolar disorder-A mega-analysis from The Enhancing Neuro Imaging Genetics through Meta-Analysis Bipolar Disorder Working Group.
Not available
S-EPMC8675404 | biostudies-literature
UnknownGenome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder.
Not available
S-EPMC3059436 | biostudies-literature
TranscriptomicsDNA methylation profiles in the uterus during subclinical endometritis
Post-partum uterine inflammation (endometritis) is associated with lower fertility at both the time of infection and after the inflammation has resolved. It was hypothesized that aberrant DNA methylation may be involved in the sub-fertility associated with post-partum uterine inflammation. The objec...
ORGANISM(S): Bos taurus 
2015-05-07 | E-GEOD-60831 | biostudies-arrayexpress
UnknownCortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group.
Not available
S-EPMC5668195 | biostudies-literature
UnknownThe Association Between Familial Risk and Brain Abnormalities Is Disease Specific: An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder.
Not available
S-EPMC7068800 | biostudies-literature
TranscriptomicsAmitriptyline-mediated cognitive enhancement in aged 3xTg Alzheimer’s disease mice is associated with neurogenesis and neurotrophic activity
Approximately 35 million people worldwide suffer from Alzheimer’s disease (AD). Existing therapeutics, while moderately effective, are currently unable to stem the widespread rise in AD prevalence. AD is associated with an increase in amyloid beta (A) oligomers and hyperphosphorylated tau, along wit...
ORGANISM(S): Mus musculus 
2011-12-31 | E-GEOD-26836 | biostudies-arrayexpress
UnknownIntelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder.
Not available
S-EPMC8675411 | biostudies-literature
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