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GenomicsXist exploits three-dimensional chromosome architecture to spread across the X-chromosome
Many large noncoding RNAs (lncRNAs) regulate chromatin, but the mechanisms by which they localize to genomic targets remain unexplored. Here we investigate the localization mechanisms of Xist during X-chromosome inactivation (XCI), a paradigm of lncRNA-mediated chromatin regulation. During the maint...
ORGANISM(S): Mus musculus 
2013-05-30 | E-GEOD-46918 | biostudies-arrayexpress
UnknownRandomized controlled trial of a video decision support tool for cardiopulmonary resuscitation decision making in advanced cancer.
Not available
S-EPMC4090424 | biostudies-literature
UnknownOptogenetically transduced human ES cell-derived neural progenitors and their neuronal progenies: Phenotypic characterization and responses to optical stimulation.
Not available
S-EPMC6844486 | biostudies-literature
GenomicsRNA-RNA interactions enable specific targeting of noncoding RNAs to nascent pre-mRNAs and chromatin sites
We developed a general method based on RNA Antisense Purification (RAP) to identify the intermolecular RNA-RNA interactions of a target RNA (RAP-RNA). RAP-RNA identifies endogenous RNA-RNA complexes through in vivo crosslinking, RNA capture with antisense oligonucleotides, and high-throughput RNA se...
ORGANISM(S): Mus musculus 
2014-09-01 | E-GEOD-55914 | biostudies-arrayexpress
TranscriptomicsCopy number analysis of OVCAR-3 and CDK2 resistant sublines
Cyclin E1 (CCNE1) is amplified in various tumor types including high-grade serous ovarian cancer where it is associated with poor clinical outcome. We have demonstrate that suppression of the Cyclin E1 partner kinase, CDK2, induces apoptosis in a CCNE1 amplicon-dependent manner. Little is known of m...
ORGANISM(S): Homo sapiens 
2013-09-01 | E-GEOD-48920 | biostudies-arrayexpress
TranscriptomicsMany Human Large Intergenic Non-coding RNAs Associate with Chromatin Modifying Complexes and Affect Gene Expression
We recently showed that the mammalian genome encodes more than a thousand large intergenic non-coding RNAs (lincRNAs) that are clearly conserved across mammals and thus functional. Gene expression patterns have implicated these lincRNAs in diverse biological processes including cell cycle regulatio...
ORGANISM(S): Homo sapiens 
2009-07-09 | E-GEOD-16226 | biostudies-arrayexpress
TranscriptomicsConsequences of GATA1 expression in Gata1- G1ME Murine Megakaryocyte/Erythrocyte Progenitor Cell Line
G1ME cells are GATA1-deficient murine bipotential megakaryocyte/erythrocyte progenitor cells derived from Gata1-negative murine ES cells. In order to assess the impact of GATA1 on gene regulation and cell differentiation, an expression construct was used to transiently produce high levels of GATA1....
ORGANISM(S): Mus musculus 
2009-06-10 | E-GEOD-14980 | biostudies-arrayexpress
TranscriptomicslincRNAs act in the circuitry controlling pluripotency and differentiation
While thousands of large intergenic non-coding RNAs (lincRNAs) have been identified in mammals, few have been functionally characterized leading to debate about their biological role. To address this, we performed loss-of-function studies on most lincRNAs expressed in mouse embryonic stem cells (ESC...
ORGANISM(S): Mus musculus 
2011-08-29 | E-GEOD-30245 | biostudies-arrayexpress
UnknownRecombination in diverse maize is stable, predictable, and associated with genetic load.
Not available
S-EPMC4378432 | biostudies-literature
GenomicsGenome-wide binding analysis of GATA1fl and GATA1s in G1ME cells.
We used chromatin immunoprecipitation sequencing (ChIP-seq) to compare genome-wide binding profiles of GATA1fl and GATA1s in G1ME cells, which are immortalized, developmentally arrested megakaryocyte-erythroid progenitors (MEPs) derived from in vitro differentiation of murine Gata1- ES cells. Althou...
ORGANISM(S): Mus musculus 
2015-01-26 | E-GEOD-61932 | biostudies-arrayexpress
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