Mitochondrial biogenesis

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Unknown (3441)
Transcriptomics (617)
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Organisms

Mus musculus (174)
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Technology Type

Mass Spectrometry (244)
Shotgun proteomics (120)
Bottom-up proteomics (53)
Affinity purification coupled with mass spectrometry proteomics (37)
Gel-based experiment (29)
Data-dependent acquisition (28)
Data-independent acquisition (27)
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SWATH MS (8)
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Mass spectrometry assay (2)
ESI (2)
DiaPASEF (2)

Instrument Platform

Q Exactive (10)
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Liquid Chromatography MS - positive - reverse phase (4)
Illumina HiSeq 2500 (3)
Illumina NovaSeq 6000 (3)
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Publication Date

2025 (118)
2026 (87)
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2021 (65)
2015 (59)
2010 (52)
2014 (50)
2020 (38)
2013 (38)
2016 (36)
2018 (34)
2017 (34)
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2008 (28)
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2012 (21)
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2005 (1)
2004 (1)

CHEBI ID

CHEBI:16113 (3)
CHEBI:32816 (3)
CHEBI:140360 (2)
CHEBI:136207 (2)
CHEBI:136220 (2)
CHEBI:71713 (2)
CHEBI:65302 (2)
CHEBI:71712 (2)
CHEBI:37154 (2)
CHEBI:741548 (2)
CHEBI:30860 (2)
CHEBI:64433 (2)
CHEBI:64516 (2)
CHEBI:64517 (2)
CHEBI:66848 (2)
CHEBI:66849 (2)
CHEBI:64549 (2)
CHEBI:64561 (2)
CHEBI:17202 (2)
CHEBI:37084 (2)
CHEBI:17786 (2)
CHEBI:70984 (2)
CHEBI:422 (2)
CHEBI:16857 (2)
CHEBI:13389 (2)
CHEBI:17750 (2)
CHEBI:27389 (2)
CHEBI:15891 (2)
CHEBI:17964 (2)
CHEBI:28842 (2)

Metabolite Name

3-Phosphoglyceric acid (3)
N-Formyl-L-methionine (2)
4-Hydroxycinnamic acid (2)
Acetylphosphate (2)
Pyrrole-2-carboxylic acid (2)
Citicoline (2)
All-trans-Retinoic acid (2)
L-Cystine (2)
Picolinic acid (2)
O-Acetylserine (2)
Homovanillic acid (2)
Betaine (2)
S-Adenosylhomocysteine (2)
Sphingosine (2)
Quinolinic acid (2)
Phosphonoacetate (2)
O-Phosphoethanolamine (2)
Nicotinamide ribotide (2)
N1-Acetylspermidine (2)
Deoxyuridine (2)
5'-Methylthioadenosine (2)
4,5-Dihydroorotic acid (2)
2-Hydroxybutyric acid (2)
1,2,3-Trihydroxybenzene (2)
L-Histidinol (2)
ADP (2)
NADP (2)
NAD (2)
L-Threonine (2)
Cholesterol (2)

First Public Date

2014 (67)
2026 (65)
2025 (60)
2024 (56)
2023 (47)
2021 (38)
2022 (32)
2020 (24)
2018 (21)
2017 (19)
2019 (15)
2015 (14)
2016 (8)
2013 (5)

Classification

fungi (6)
protozoa (1)

Modification

0.9840160012245178 (1)
15.994915008544922 (1)
57.02146530151367 (1)

Study type

Transcription profiling by array (179)
RNA-seq of coding RNA (38)
RNA-seq of non coding RNA (18)
Unknown experiment type (8)
Other (8)
ChIP-seq (7)
ChIP-chip by tiling array (3)
Transcription profiling by RT-PCR (3)
Methylation profiling by high throughput sequencing (2)
RNA-seq of total RNA (2)
Transcription profiling by SAGE (1)
Human - High-throughput sequencing (1)
Cell line - High-throughput sequencing (1)
Transcription profiling by tiling array (1)
Comparative genomic hybridization by array (1)
DNA-seq (1)

Release Date

2022 (362)
2021 (342)
2025 (339)
2023 (306)
2020 (298)
2024 (271)
2019 (223)
2018 (220)
2017 (192)
2015 (184)
2016 (183)
2014 (151)
2013 (105)
2010 (97)
2012 (96)
2011 (91)
2008 (63)
2009 (52)
2026 (50)
2007 (40)
2006 (19)
2005 (11)
2004 (7)
1998 (3)
2003 (2)
2002 (1)
2001 (1)
1999 (1)

Lab affiliation

Chair of Biochemistry II, Theodor Boveri-Institute, Biocenter, University of Würzburg, Würzburg, Germany (9)
Department of Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology and BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg im Breisgau, Germany (6)
Max-Planck-Institute for Biology of Ageing Department of Mitochondrial Proteostasis Joseph-Stelzmann-Str. 9b 50931 Cologne (6)
University of Miami School of Medicine (4)
Institute for Biochemistry, University of Cologne (3)
Max-Planck-Institute for Biology of Ageing Department of Mitochondrial Proteostasis Joseph-Stelzmann-Str. 9b 50931 Cologne Germany (3)
Molecular Genetics, RPTU Kaiserslautern, Germany (3)
University of Wisconsin-Madison (3)
Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Centre Cambridge CB2 0RE United Kingdom (2)
Center for Molecular Biology of Heidelberg University (ZMBH), 69120 Heidelberg, Germany (2)
College of Agronomy, Jiangxi Agricultural University (2)
Core Facility for Mass Spectrometry and Proteomics, Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany (2)
Dana-Farber Cancer Institute and Harvard Medical School (2)
Department of Biochemistry University of Wisconsin-Madison (2)
Department of Biochemistry and Molecular Biology, The Bio21 Institute, The University of Melbourne, 3000, Melbourne, Australia (2)
Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany (2)
Laboratory of Bioenergetics Institute of Physiology, Czech Academy of Sciences Prague Czech Republic (2)
Laboratory of Molecular Basis of Synaptic Plasticity Centre of New Technologies, University of Warsaw (2)
Max-Planck-Institute for Biology of Ageing Department of Mitochondrial Proteostasis Joseph-Stelzmann-Str. 9b 50931 Cologne, Germany (2)
Molecular Genetics RPTU Kaiserslautern (2)
Molecular Genetics, TU Kaiserslautern (2)
School of Integrative Plant Science Plant Biology Section, Cornell University (2)
Structural Biology Group, European Synchrotron Radiation Facility (ESRF), Grenoble, France (2)
The Rockefeller University (2)
University of Vienna, Faculty of Chemistry, Department of Analytical Chemistry (2)
(Head, NHS Highly Specialised Mitochondrial Diagnostic Laboratory and Professor of Mitochondrial Pathology), Wellcome Centre for Mitochondrial Research, Newcastle University, UK (1)
-Harry Perkins Institute of Medical Research, Nedlands, Western Australia 6009, Australia -School of Pharmacy and Biomedical Sciences, Curtin University, Bentley, Western Australia 6102, Australia -Curtin Health Innovation Research Institute, Curtin University, Bentley, WA 6102, Australia (1)
1.Department of Molecular Biology and Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA 02114, USA, 2.Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA, 3.Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. (1)
1Molecular Cell Biology, Institute of Cell Biology, University of Tübingen (1)
ARC Centre of Excellence in Plant Energy Biology at The University of Western Australia (1)

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Human Milk-Derived 5′-UMP Promotes Thermogenesis and Mitochondrial Biogenesis to Ameliorate obesity

Background: Traditional obesity interventions are often unsuitable for children. Breastfeeding has been shown to reduce obesity risk, potentially through bioactive metabolites in human milk. Here, we identified a human milk-derived metabolite, uridine 5'-monophosphate (5'-UMP), whose role in lipi...

2025-09-23 | MTBLS13027 | MetaboLights

Ribosomal mistranslation leads to silencing of the unfolded protein response and increased mitochondrial biogenesis

Translation fidelity is the limiting factor in the accuracy of gene expression. With an estimated frequency of 10-4, errors in mRNA decoding occur in a mostly stochastic manner. Little is known about the response of higher eukaryotes to chronic loss of ribosomal accuracy as per an increase in the...

2019-09-17 | MTBLS106 | MetaboLights

A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate

Mitochondrial fatty acid oxidation (FAO) is essential for hematopoietic stem cell (HSC) self-renewal; however, the mechanism by which mitochondrial metabolism controls HSC fate remains unknown. Here, we show that within the hematopoietic lineage, HSCs have the largest mitochondrial NADPH pools, w...

2025-07-07 | MTBLS6401 | MetaboLights

Mitochondrial glutamine import sustains mitochondrial translation independent of glutaminolysis in cancer_GlnFlux_untargeted metabolites

Oxidative phosphorylation (OXPHOS) fulfills energy metabolism and biosynthesis through tricarboxylic acid (TCA) cycle and an intact electron transport chain (ETC). Mitochondrial glutamine import (MGI) replenishes TCA cycle through glutaminolysis, but its broader roles in cancer remains unclear. H...

2025-09-29 | MTBLS13074 | MetaboLights

Mitochondrial glutamine import sustains mitochondrial translation independent of glutaminolysis in cancer_targeted metabolites

2025-09-29 | MTBLS13076 | MetaboLights

Mitochondrial glutamine import sustains mitochondrial translation independent of glutaminolysis in cancer_A549 cell culture_untargeted metabolites_U_13gln/glc

2025-09-29 | MTBLS13075 | MetaboLights

Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation and gut microbiota composition in a twin study

Not available

ORGANISM(S): Homo sapiens

ST002141 | MetabolomicsWorkbench

MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with Host Cell Factor-1

Not available

ORGANISM(S): Homo sapiens

ST001429 | MetabolomicsWorkbench

Looking for mitochondrial associated RNA

We investigated the peripheral mitochondrial localization of nuclear-encoded mRNAs (MLR) in various conditions in which translation was inhibited or the mRNA binding protein context altered (Delta puf3). We used cell fractionation protocols together with microarray to assess the distribution of mRNA...

ORGANISM(S): Saccharomyces cerevisiae

2008-06-01 | E-GEOD-9393 | biostudies-arrayexpress

Defective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in liver

Mitochondrial oxidative phosphorylation (OXPHOS) fuels cellular ATP demands. OXPHOS defects lead to severe human disorders with unexplained tissue specific pathologies. Mitochondrial gene expression is essential for OXPHOS biogenesis since core subunits of the complexes are mitochondrial-encoded. CO...

2024-07-19 | MTBLS9823 | MetaboLights

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