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MetabolomicsIntracellular iron overload rewires HSC metabolism by impairing mitochondrial fitness
Iron is an essential element for several cellular processes and recent evidence highlighted its role in regulating the function of hematopoietic stem cells (HSCs). When in excess it reduces quiescence and self-renewal, however, whether and how iron influences HSC metabolism is still unknown. Here, w...
2024-12-04 | MTBLS11778 | MetaboLights
MetabolomicsGenotype to phenotype: Diet-by-mitochondrial DNA haplotype interactions drive metabolic flexibility and organismal fitness
Diet may be modified seasonally or by biogeographic, demographic or cultural shifts. It can differentially influence mitochondrial bioenergetics, retrograde signalling to the nuclear genome, and anterograde signalling to mitochondria. All these interactions have the potential to influence the freque...
2018-11-07 | MTBLS724 | MetaboLights
MetabolomicsImmunoglobulin expression in the endoplasmic reticulum shapes the metabolic fitness of B lymphocytes
The major function of B lymphocytes is to sense antigens and to produce protective antibodies after activation. This function requires the expression of a B-cell antigen receptor (BCR), and evolutionary conserved mechanisms seem to exist that ensure that B cells without a BCR do not develop nor surv...
2020-04-21 | MTBLS186 | MetaboLights
MetabolomicsMulti‐omics identify xanthine as a pro‐survival metabolite for nematodes with mitochondrial dysfunction
Aberrant mitochondrial function contributes to the pathogenesis of various metabolic and chronic disorders. Inhibition of insulin/IGF-1 signaling (IIS) represents a promising avenue for the treatment of mitochondrial diseases, although many of the molecular mechanisms underlying this beneficial effe...
2019-02-28 | MTBLS794 | MetaboLights
GenomicsMitochondrial fitness and risk of pancreatic ductal adenocarcinoma
Mitochondrial fitness and risk of pancreatic ductal adenocarcinoma
PRJNA810442 | ENA
ProteomicsMitochondrial phosphoproteomes are functionally specialized across tissues
Mitochondria are essential organelles involved in critical biological processes such as energy metabolism and cell survival. Their dysfunction is linked to numerous human pathologies that often manifest in a tissue-specific manner. Accordingly, mitochondria fitness depends on versatile proteomes spe...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-03 | PXD030062 | Pride
Mitochondrial dynamics Oxidative phosphorylation Proteomics Mass spectrometry Mitochondria : phosphorylation Systems biology Mouse tissues 
GenomicsMetabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species
Metabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species
PRJNA663327 | ENA
GenomicsMyeloid-derived suppressor cells mitochondrial fitness governs chemotherapeutic efficacy in hematologic malignancies
Myeloid-derived suppressor cells mitochondrial fitness governs chemotherapeutic efficacy in hematologic malignancies
PRJNA1070688 | ENA
ProteomicsDeficiency in Sirtuin3 rewires mitochondrial metabolism and increases maximum lifespan under caloric restriction - Mitochondrial Acetylation Stoichiometry
Quantification of acetylation stoichiometry from mitochondrial enriched proteins from mouse livers. Conditions compared include genotype, diet, and age; i.e. Sirt3 KO vs Sirt3 WT, caloric restricted (CR) diet vs control diet (CD), and 5 months old vs 25 months old.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-03-23 | MSV000087085 | MassIVE
UnknownMitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila.
Not available
S-EPMC6650417 | biostudies-literature
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